BIOMEDICAL ENGINEERING

The fluorescence and brightfield, section and image, whole mouse, Case cryo-imaging system uniquely provides micron resolution and information-rich contrast mechanisms over very large 3D fields of view. Cryo-imaging is used in a variety of applications, including mouse and embryo anatomical phenotyping, drug delivery, imaging agents, metastastic cancer, stem cells, and very high resolution vascular imaging, among many. In demonstration experiments, we have applied this technology for obtaining tiled high resolution images of an entire mouse, detection of fluorescently tagged cancer cells, multi-modality imaging involving MRI and cryo-imaging, fluorescence imaging of transgenic mice as well as mouse embryo imaging, among others. Cryo-imaging fills the gap between whole animal in vivo imaging and histology, allowing one to image a mouse along the continuum from the mouse → organ → tissue structure → cell → sub-cellular domains.

Host: Professor David Wilson