BME Spring 2008 Seminar Series
Wickenden Building - Room 322
12:00 pm - 1:00 pm
Thursday, February 14, 2008
Engineering an Ecosystem: Taking Cues from Nature's Paradigm to Build Tissue in the Lab and the Body
Melissa Knothe Tate, Ph.D.
Associate Professor, Biomedical Engineering and
Mechanical & Aerospace Engineering
Case Western Reserve University
Cleveland, OH
Dr. Knothe Tate will first present top-down engineering approaches used previously by her "MechBio" team to elucidate the "ecosystem bone" which osteocytes, osteoblasts, osteoclasts and pluripotent stem cells inhabit. Then she will show how recent insights from study of mechanically modulated transport of extrinsic signals in bone can be used, in a bottom-up approach, to harness nature's development and healing capacities for engineering tissue and to apply nature's paradigm for the development of a novel class of mechanoactive materials.
Suggested related readings:
Reading 1
Reading 2
Reading 3
Reading 4
Other Links:
Case BME MechBio
Dr. Knothe Tate's faculty profile
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