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BIOMEDICAL ENGINEERING
 
 
 
 

Other Biomedical Engineering Research

 DOWNLOAD OTHER BIOMEDICAL ENGINEERING RESEARCH BROCHURE
 

• Cardiovascular Systems
 

• Cardiac Bioelectricity
 

• Biomechanical Systems
 

• Biomedical Sensors
 

• Metabolic Systems


Cardiovascular Systems

Research in cardiovascular systems at Case aims to develop and apply novel technologies to the understanding of normal cardiac physiology, the pathogenesis of cardiac diseases, the development of therapeutic technologies. State-of-the-art imaging technologies, and mathematical modeling are combined with molecular biology methods to the study of various aspects of the cardiovascular system, from vascular biology to cardiac biomechanics. Engineering principles and multidisciplinary approaches are employed for integrative characterization of the cardiovascular system from gene regulation to in vivo functions.


Cardiovascular Systems Faculty


Cardiac Bioelectricity

Heart disease is the most common cause of death in the United States and all Western Societies. Most cardiovascular deaths are caused by an electrical rhythm disturbance (i.e. cardiac arrhythmia). Future advances in the diagnosis and treatment of cardiac arrhythmias are critically dependent on a broad range of integrated research programs that emphasize a bench-to-bedside approach. Research programs utilize state-of-the-art experimental techniques and promote cross-fertilization between clinicians, clinical investigators, epidemiologists, physiologists, cell and molecular biologists, mathematicians, and biomedical engineers.

    Recent Research Activities
  •  Cell and gene therapy for arrhythmias
  •  Device and ECG signal processing technologies
  •  Novel cellular and molecular imaging
  •  Ion channel structure and function
  •  Arrhythmia mechanisms


Cardiac Bioelectricity Faculty


Biomechanical Systems

The study of biomechanics is the use of engineering mechanics to study the structure and function of biomelogical systems. At Case BME, theoretical analyses, numerical models, and experimental methods are used in combination to more fully understand physiological systems and to design clinical interventions ranging from artificial joints and prosthetic limbs to dental implants and bone healing. Biomechanics study also leads to improvements in the comfort and safety of autmobiles and work environments.

    Recent Research Activities
  •  Computational musculoskeletal modeling
  •  Bone biomechanics
  •  Control of neuroprostheses for motor function
  •  Neuromuscular control systems
  •  Human locomotion


Biomechanical Systems Faculty

Biomedical Sensors

Biomedical sensing is an important field of study in Biomedical Engineering because it is widely used in academic research as well as in clinical settings. Research in this field at Case includes development and use of electrochemical and optical mini- to micro-sensors for in vitro as well as in vivo applications. Besides electrochemical and optical sensors, micro-fabricated devices such as BioMEMS chips are also being developed for sensing applications.

    Recent Research Activities
  •  Sliver color-changing glucose/ion sensor
  •  Quantitative characteristics of cellular transport and communication
  •  Cost effective in vitro diagnostics
  •  Continuous in vivo diagnostics
  •  Micro-machining of BioMEMS electrochemical sensors


Biomedical Sensors Faculty

Metabolic Systems

The Center for Modeling Integrated Metabolic Systems (MIMS) researchers use mathematical modeling and computer simulation to analyze changes in cellular metabolism of the heart, skeletal muscle, brain and liver as well as their integrated effects in the human body. The metabolic changes of interest are associated with exercise, diet and disease.

    Recent Research Activities
  •  Cellular metabolic and transport processes of major tissue/organ systems linked to physiological responses
  •  Heat transfer and thermal damage modeling of tissue for tumor ablation under MR guidance
  •  Drug and biological agent delivery and metabolism in tissues.
  •  Mathematical modeling, parameter estimation, and optimal experiment design of dynamic systems.

The Center for Modeling Integrated Metabolic Systems was recently featured in the Case Value of Research publication. Read the full story.


Metabolic Systems Faculty


Faculty

Faculty
Research Interests
Email Address
Cardiovascular Systems
CHENG,
Yuanna		 Cardiac imaging, mechanisms of arrhythmias, implantable defibrillators, cardiac remodeling, antiarrhythmic therapy chengy@ccf.org
CHISHOLM,
Guy M.		 Low density lipoprotein (LDL) transport into arterial tissue. Role of LDL oxidation in atherosclerosis. Alterations in cell and tissue function induced by oxidized LDL (oxLSL), including oxLDL-induced apoptosis, proliferation and gene expression in vascular cells. chisolg@ccf.org
DESCHENES,
Isabelle >>		 Molecular imaging, ion channel structure and function, genetic regulation of ion channels, cellular and molecular mechanisms of cardiac arrhythmias ideschenes@metrohealth.org
LAURITA,
Kenneth >>		 Cellular mechanisms of cardiac arrhythmias using fluorescent imaging techniques, instrumentation and software design for real-time cardiac mapping krl2@case.edu
PENN,
Mark		 Myocardial ischemia, vascular biology, cardiac critical care pennm@ccf.org
ROSENBAUM,
David S.		 Cellular mechanisms of cardiac arrhythmias, fluorescent imaging of transmembrane potential and intracellular calcium; cardiac repolarization; impulse propagation and block; instrumentation and software for imaging electrical activity drosenbaum@metrohealth.org
THOMAS,
James		 Echocardiography  
WALDO,
Albert L.		 Cardiac electrophysiology and cardiac excitation mapping alw2@case.edu
YU,
Xin		 MRI and MRS for characterization of cardiac disease. xin.yu@case.edu
Cardiac Bioelectricity
CHENG,
Yuanna		 Cardiac imaging, mechanisms of arrhythmias, implantable defibrillators, cardiac remodeling, antiarrhythmic therapy chengy@ccf.org
DESCHENES,
Isabelle >>		 Molecular imaging, ion channel structure and function, genetic regulation of ion channels, cellular and molecular mechanisms of cardiac arrhythmias ideschenes@metrohealth.org
LAURITA,
Kenneth >>		 Cellular mechanisms of cardiac arrhythmias using fluorescent imaging techniques, instrumentation and software design for real-time cardiac mapping krl2@case.edu
ROSENBAUM,
David S.		 Cellular mechanisms of cardiac arrhythmias, fluorescent imaging of transmembrane potential and intracellular calcium; cardiac repolarization; impulse propagation and block; instrumentation and software for imaging electrical activity drosenbaum@metrohealth.org
WALDO,
Albert L.		 Cardiac electrophysiology and cardiac excitation mapping alw2@case.edu
Biomechanical Systems
CAVANAGH,
Peter R.		 Foot complications of diabetes, bone biomechanics cavanap@ccf.org
DAVIS,
Brian		 Human locomotion and biomechanics davisb3@ccf.org
KNOTHE TATE,
Melissa		 Mechanobiology of musculoskeletal systems. Cellular and orthopaedic biomechanics. Implant design. cmd22@case.edu
van den BOGERT,
Antonie		 Computational musculoskeletal modeling and experimental analysis of human posture and locomotion bogerta@ccf.org
Biomedical Sensors
GRATZL,
Miklos		 Biochemical sensors; fine chemical manipulation of microdroplets and single cells; cancer research and neurochemistry at the single cell level; cost-effective biochemical diagnostics in microliter body fluids mxg13@case.edu
FLEISCHMAN,
Aaron		 Development of microelectromechanical systems (MEMS) technology for biomedical applications - BioMEMS fleisca@ccf.org
ROY,
Shuvo		 Development of microelectromechanical systems (MEMS) technology for biomedical applications - BioMEMS roys@ccf.org
Metabolic Systems
CABRERA,
Marco E.		 Modeling and control of metabolic processes; metabolic regulation in hypoxia, ischaemia and exercise mec6@case.edu
SAIDEL,
Gerald		 Mass & heat transport and metabolic analysis in cells, tissues, & organs; mathematical modeling, simulation, parameter estimation; optimal experimental design; metabolic dynamics; minimally invasive thermal tumor ablation; slow release drug delivery gms3@case.edu

This page was last modified December 14, 2007