Research in biomedical systems, sensors, and simulation involves acquiring biological
information at multiple scales with state-of-the-art methodologies, multi-scale
integration of mechanisms and phenomena with computational models, and
simulation and analysis of acute and chronic physiological system behavior.
Download the Biomedical Systems Brochure
Biomedical Sensors
Biomedical sensing integrates biologically derived sensing components with a
transducer for in vitro and in vivo measurements of chemical and biological
substances. Research includes the development and use of electrochemical,
optical mini- and micro-sensors, micro-fabricated devices such as BioMEMS
chips, quantitative analysis of cellular transport and communication, cost-effective
in vitro diagnostics, and continuous in vivo diagnostics.
Metabolic Systems
Mathematical modeling and computer simulation are used to analyze changes
in cellular metabolism of tissues, organs, and the whole body. Non-invasive
or minimally invasive measurements are obtained with human exercise studies
under normal and diseased conditions. Cellular metabolic changes are quantitatively
related to physiological changes. Projects include cellular metabolic mechanisms of
myocardial ischemia, cellular metabolism and energetics in skeletal muscle, adipose
tissue metabolism with insulin resistance, and whole-body energy balance.
Cardiac and Vascular Systems
Cellular and molecular imaging technologies and mathematical modeling are
combined with molecular, cellular, and tissue measurements to analyze mechanisms
of heart disease. Therapeutic strategies are developed related to biomechanical,
vascular, and electrophysiological functions. Cardiovascular physiology and
metabolic regulation are studied using ECG signals, magnetic resonance imaging,
optical mapping, and spectroscopy. Projects include cellular mechanisms of sudden
cardiac death, cell and gene therapy for arrhythmias, ion channel structure and
function, and myocardial ischemia.
Musculoskeletal Mechanics
Engineering mechanics is applied to study the structure and function of
musculoskeletal systems. This research leads to the design of clinical interventions
including artificial joints, prosthetic limbs, dental implants, bone healing, and methods
to counteract loss of bone and muscle during space travel. Projects include computational
musculoskeletal modeling, bone biomechanics, muscular control systems,
human locomotion, and exercise to reduce loss of musculoskeletal function in space.
Affiliated Labs and Centers
Laboratory for Biomedical Sensing
Experimental and Computational Mechanobiology Laboratories
Cardiovascular Research and Imaging Center
The Heart and Vascular Research Center (HVRC), MetroHealth Medical Center
Modeling and Analysis of Physiological Systems
Faculty
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Faculty
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Research Interests
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Email Address
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| Biomedical Sensors |
GRATZL,
Miklos |
Biochemical sensing and diagnostics in vitro and in vivo; electrochemical and optical micro-techniques; MEMS for assessing cellular transport; cancer pharmacology at the single cell level; sliver sensor for multianalyte patient monitoring |
mxg13@case.edu |
| Metabolic
Systems |
CABRERA,
Marco E. |
Modeling and control
of metabolic processes; metabolic regulation in hypoxia,
ischaemia and exercise |
mec6@case.edu |
SAIDEL,
Gerald |
Mass & heat transport
and metabolic analysis in cells, tissues, & organs;
mathematical modeling, simulation, parameter estimation;
optimal experimental design; metabolic dynamics;
minimally invasive thermal tumor ablation; slow release
drug delivery |
gms3@case.edu |
| Cardiac and Vascular Systems |
CHENG,
Yuanna |
Cardiac imaging, mechanisms of arrhythmias, implantable defibrillators, cardiac remodeling, antiarrhythmic therapy |
chengy@ccf.org |
DESCHENES,
Isabelle >> |
Molecular imaging, ion
channel structure and function, genetic regulation
of ion channels, cellular and molecular mechanisms
of cardiac arrhythmias |
ideschenes@metrohealth.org |
DONAHUE,
J. Kevin >> |
Mechanisms for cardiac arrhythmias; cardiac electrophysicology; in vivo cardiac mapping; gene delivery systems and methods; gene therapy |
kdonahue@metrohealth.org |
LAURITA,
Kenneth >> |
Novel biological therapies for sudden cardiac death; cellular mechanisms of cardiac arrhythmias using fluorescent imaging of transmembrane potential and intracellular calcium;
instrumentation and software design for real-time cardiac mapping |
krl2@case.edu |
ROSENBAUM,
David S. |
Cellular mechanisms of
cardiac arrhythmias, fluorescent imaging of transmembrane
potential and intracellular calcium; cardiac repolarization;
impulse propagation and block; instrumentation and
software for imaging electrical activity |
drosenbaum@metrohealth.org |
WALDO,
Albert L. |
Cardiac electrophysiology
and cardiac excitation mapping |
alw2@case.edu |
PENN,
Mark |
Myocardial ischemia,
vascular biology, cardiac critical care |
pennm@ccf.org |
THOMAS,
James |
Echocardiography |
|
YU,
Xin |
MRI and MRS for characterization of cardiac disease |
xin.yu@case.edu |
| Musculoskeletal Mechanics |
KNOTHE
TATE,
Melissa |
Harnessing nature's development and healing capacities; applying nature's paradigm to develop novel mechnoactive materials; mechanically modulated transport in tissues and biomaterials |
knothetate@case.edu |
van
den BOGERT,
Antonie |
Computational musculoskeletal modeling and experimental analysis of human posture and locomotion |
bogerta@ccf.org |
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