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The rapidly growing field of biomedical imaging
enables one to visualize physiological structures, measure
biological functions, and evaluate cellular and molecular events
without requiring invasive procedures. Applicable modalities
include: magnetic resonance imaging (MRI); positron emission
tomography (PET); single photon emission coherence tomography
(SPECT); ultrasound imaging; optical coherence tomography (OCT);
computed (x-ray) tomography; bioluminescence imaging; fluorescence
imaging; and other optical imaging methods. Case BME was awarded
$12 million for the Wright Center of Innovation in Imaging,
which has been leveraged to develop The Northeast Ohio Small
Animal Imaging Center. This state-of-the-art research space
includes several high-field MRI scanners, nuclear microPET
and SPECT/CT scanners, OCT and bioluminescence imaging systems,
and support faciities for animal husbandry & preparation,
image processing & analysis, and histopathology. Additionally,
other laboratories are available for high frequency ultrasound
imaging, targeted radionuclide synthesis and radiofrequency
electronics fabrication.
Recent Research Activities
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MRI applied to the cardiovascular system and cancer detection |
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Biomedical Image Processing |
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Intravascular Ultrasound |
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Biophotonics and Optical Coherence Tomography |
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In vivo cellular and molecular imaging |
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Positron Emission Tomography of the brain, cancer and
cardiovascular disease |
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Interventional Magnetic Resonance Imaging (MRI) for minimally
invasive treatment of cancer and blood vessel disease |
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Bioluminescence Imaging of Gene Expression |
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Ultrasound Tissue Characterization, High Intensity Focused
Ultrasound Ablation |
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Novel MRI and Ultrasound Imaging Contrast Agents and
PET Radiotracers |
Biomedical Imaging Faculty
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Primary Faculty
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Research Interests
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Email Address
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BASILION,
James |
High resolution imaging of endogenous gene expression;
definition of "molecular signatures" for
imaging and treatment of cancer and other diseases;
generating and utilizing genomic data to define informative
targets; strategies for applying non-invasive imaging
to drug development; novel molecular imaging probes
and paradigms. |
james.basilion@case.edu |
BROOME,
Ann-Marie |
Molecular imaging of complex signatures in cancer, in vivo/in vitro imaging of cellular mechanisms in differentiation, inflammation, and carcinogenesis, signaling of chemotactic peptides in epithelia. |
ann-marie.broome@case.edu |
HU,
Zhilin |
Applied optics including optical remote sensing biomedical imaging and laser spectroscopy; optical instrumentation including theoretical modeling to system and components design; for applications in clinical GI endoscopies, pulmonary studies, skin and cardiac diseases, and disease prevention. |
zhilin.hu@case.edu |
PAGEL,
Marty |
Development of new 'activatable'
MRI contrast agents that detect the presence of functional
or molecular markers of disease and new MRI methods
for high-throughput screenings. |
mpagel@case.edu |
ROLLINS,
Andrew M. |
Biomedical diagnosis, novel
optical methods for high-resolution, minimally invasive
imaging, tissue characterization and analyte sensing, real-time
microstructural and functional imaging using coherence
tomography |
rollins@case.edu |
WILSON,
David L. |
Medical image processing; image
segmentation, registration, and analysis; quantitative
image quality of X-ray fluoroscopy and fast MRI; interventional
MRI treatment of cancer |
dlw@case.edu |
YU,
Xin |
Cardiovascular physiology;
magnetic resonance imaging and spectroscopy; characterization
of the structure-function and energy-function relationships
in normal and diseased hearts; small animal imaging and
spectroscopy. |
xin.yu@case.edu |
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Associated Faculty
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Research Interests
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Email Address
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BROOME,
Ann-Marie |
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ann-marie.broome@case.edu |
DEAN,
David |
3-D medical imaging and morphometrics;
skull, brain, soft tissue face. |
david.dean@case.edu |
DIAZ,
Pedro J. |
Magnetic resonance imaging;
image processing. |
pjd2@case.edu |
DUERK,
Jeffrey L. |
Magnetic resonance imaging;
flow visualization; interventional imaging. |
duerk@uhrad.com |
EXNER,
Agata A. |
Image-guided drug delivery,
functional CT and MRI, polymers for interventional radiology
applications, cellular and animal models of cancer. |
exner@uhrad.com |
FEI,
Baowei |
Quantitative image analysis,
multimodality image registration, fusion visualization,
image-guided minimally invasive therapy, prostate cancer,
photodynamic therapy. |
fei@uhrad.com |
FISHER,
Elizabeth |
Quantitative image analysis
for monitoring multiple sclerosis. |
fishere@ccf.org |
FLASK,
Chris |
MR imaging and spectroscopy acquisition and reconstruction
algorithms to assess molecular mechanisms of cancer and diabetes /
metabolic syndrome progression and therapeutic efficacy.
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flask@uhrad.com |
GRISWOLD,
Mark |
Magnetic resonance imaging: parallel imaging, hardware design, rapid acquisitions. |
griswold@uhrad.com |
LEE,
Zhenghong |
Quantitative PET and SPECT
imaging, multimodal image registration, 3D visualization,
molecular imaging and small animal imaging systems. |
zxl11@case.edu |
MUZIC,
Raymond F., Jr. |
Experiment design and analysis
for positron emission tomography. |
rfm2@case.edu |
NOUR,
Sherif |
Development of new interventional
MRI techniques and percutaneous thermal ablation therapies
for cancer treatment, sleep apnea, and other biomedical
applications. |
nour@uhrad.com |
RZESZOTARSKI,
Mark S. |
Radiological imaging; magnetic
resonance imaging, ultrasound. |
msr7@case.edu |
TKACH,
Jean |
Functional MR imaging. |
tkach@uhrad.com |
VINCE,
D. Geoffrey |
Image and signal processing
of intravascular ultrasound images, mechanics of coronary
plaque rupture, cellular aspects of atherosclerosis. |
vinced@ccf.org |
WANG,
Yanming |
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wang@uhrad.com |
Affiliated Labs and Centers
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