MECHBIO

• 

Knothe Tate M.L. (2007) Multi-scale computational engineering of bones: state of the art insights for the future. In: Bone Tissue Engineering (Ed.: F. Bronner, C. Farach-Carson, A. Mikos), Chapter 10, Springer-Verlag, London, 10: 141-160.

• 

Anderson E.A., Kreuzer S.M. , Small O., Knothe Tate M.L. (2007) Pairing computational and scaled physical models to determine permeability as a measure of cellular communication in micro- and nano-scale pericellular spaces. Microfluidics and Nanofluidics,in press.

• 

Knothe Tate M.L., Ritzman T., Schneider E., Knothe U. (2007) Testing of a New One Stage Surgical Procedure Exploiting the Periosteum and Bone Transport for Repair of Long Bone Defects, Journal of Bone and Joint Surgery,

• 

Anderson EJ, Falls TD, Sorkin AM, Knothe Tate ML. The imperative for controlled mechanical stresses in unraveling cellular mechanisms of mechanotransduction. Biomed Eng Online. 2006 May 3;5:27

• 

Steck R, Tate ML. In silico stochastic network models that emulate the molecular sieving characteristics of bone. Ann Biomed Eng. 2005 Jan;33(1):87-94

• 

Anderson EJ, Kaliyamoorthy S, Iwan J, Alexander D, Knothe Tate ML. Nano-microscale models of periosteocytic flow show differences in stresses imparted to cell body and processes. Ann Biomed Eng. 2005 Jan;33(1):52-62.

• 

Sorkin AM, Dee KC, Knothe Tate ML. "Culture shock" from the bone cell's perspective. emulating physiological conditions for mechanobiological investigations. Am J Physiol Cell Physiol. 2004 Dec;287(6):C1527-36. Epub 2004 Aug 18.

• 

Tami AE, Schaffler MB, Knothe Tate ML. Probing the tissue to subcellular level structure underlying bone's molecular sieving function. Biorheology. 2003;40(6):577-90.

• 

Knothe Tate ML, Adamson JR, Tami AE, Bauer TW. The osteocyte. Int J Biochem Cell Biol. 2004 Jan;36(1):1-8.

• 

Tami AE, Nasser P, Schaffler MB, Knothe Tate ML. Noninvasive fatigue fracture model of the rat ulna. J Orthop Res. 2003 Nov;21(6):1018-24.

• 

Knothe Tate ML. "Whither flows the fluid in bone?" An osteocyte's perspective. J Biomech. 2003 Oct;36(10):1409-24. Review.

• 

Mishra S, Knothe Tate ML. Effect of lacunocanalicular architecture on hydraulic conductance in bone tissue. implications for bone health and evolution. Anat Rec. 2003 Aug;273A(2):752-62.

• 

Steck R, Niederer P, Knothe Tate ML. A finite element analysis for the prediction of load-induced fluid flow and mechanochemical transduction in bone. J Theor Biol. 2003 Jan 21;220(2):249-59.

• 

Tami AE, Nasser P, Verborgt O, Schaffler MB, Knothe Tate ML. The role of interstitial fluid flow in the remodeling response to fatigue loading. J Bone Miner Res. 2002 Nov;17(11):2030-7.

• 

Knapp HF, Reilly GC, Stemmer A, Niederer P, Knothe Tate ML. Development of preparation methods for and insights obtained from atomic force microscopy of fluid spaces in cortical bone. Scanning. 2002 Jan-Feb;24(1):25-33.

• 

Reilly GC, Knapp HF, Stemmer A, Niederer P, Knothe Tate ML. Investigation of the morphology of the lacunocanalicular system of cortical bone using atomic force microscopy. Ann Biomed Eng. 2001 Dec;29(12):1074-81.

• 

Knothe Tate ML. Mixing mechanisms and net solute transport in bone. Ann Biomed Eng. 2001 Sep;29(9):810-1; author reply 812-6.

• 

Knothe U, Knothe Tate ML, Klaue K, Perren SM. Development and testing of a new self-locking intramedullary nail system: testing of handling aspects and mechanical properties. Injury. 2000 Oct;31(8):617-26.

• 

Knothe Tate ML, Steck R, Forwood MR, Niederer P. In vivo demonstration of load-induced fluid flow in the rat tibia and its potential implications for processes associated with functional adaptation. J Exp Biol. 2000 Sep;203 Pt 18:2737-45.

• 

Steck R, Niederer P, Knothe Tate ML. A finite difference model of load-induced fluid displacements within bone under mechanical loading. Med Eng Phys. 2000 Mar;22(2):117-25.

• 

Gardner TN, Stoll T, Marks L, Mishra S, Knothe Tate M. The influence of mechanical stimulus on the pattern of tissue differentiation in a long bone fracture--an FEM study. J Biomech. 2000 Apr;33(4):415-25.

• 

Knothe Tate ML, Knothe U. An ex vivo model to study transport processes and fluid flow in loaded bone. J Biomech. 2000 Feb;33(2):247-54.

• 

Gatzka C, Schneider E, Knothe Tate ML, Knothe U, Niederer P. A novel ex vivo model for investigation of fluid displacements in bone after endoprosthesis implantation. J Mater Sci Mater Med. 1999 Dec;10(12):801-6.

• 

Knothe Tate ML, Knothe U, Niederer P. Experimental elucidation of mechanical load-induced fluid flow and its potential role in bone metabolism and functional adaptation. Am J Med Sci. 1998 Sep;316(3):189-95.

• 

Knothe Tate ML, Niederer P, Knothe U. In vivo tracer transport through the lacunocanalicular system of rat bone in an environment devoid of mechanical loading. Bone. 1998 Feb;22(2):107-17.

Recent Presentations

• 

Steck R. Patel R, Schütz M, Knothe Tate M.L. Diffusivity of rat bone predicted by stochastic network models compared with results from FRAP experiments, 5th World Congress of Biomechanics, Munich, 29 July – 4 August, 2006, podium presentation.

• 

nderson E., Knothe Tate M.L. Idealization of pericellular fluid space geometry strongly influences the prediction of local stresses imparted by fluid drag on cell surfaces, 5th World Congress of Biomechanics, Munich, 29 July – 4 August, 2006, poster presentation, 7448.

• 

Knothe Tate M.L. In Situ Imaging of Bone Cells: Opportunities for Elucidating a Cellular Basis of Bone Disease and Challenges for Clinical Translation, 5th World Congress of Biomechanics, Munich, 29 July – 4 August, 2006, invited keynote podium presentation, 7861.

• 

Kreuzer S., Knothe U., Knothe Tate M.L. Virtual mechanical loading model to elucidate mechanobiological modulation of endogenous tissue engineering strategies, 5th World Congress of Biomechanics, Munich, 29 July – 4 August, 2006, poster presentation, 7601.

• 

Sorkin A.M., Knothe Tate M.L. A System of In Situ Osteocyte Organ Culture Models for Mechanobiological Study of Bone, 5th World Congress of Biomechanics, Munich, 29 July – 4 August, 2006, podium presentation, 7231.

• 

Anderson E, Knothe Tate ML. Impact of Physiologic Geometry in Predicting Forces Imparted Locally to Cells through Load-Induced Fluid Flow, Transactions of the Orthopaedic Research Society, Chicago, IL, 19 – 22 March, 2006, 31: 0124, podium presentation.

• 

Anderson E, Cooke M, Savrin J, Dean D, Knothe Tate ML. Optimization of Tissue Engineering Scaffold Architectures and Flow Regimes for Cell Cultivation, Transactions of the Orthopaedic Research Society, Chicago, IL, 19 – 22 March, 2006, 31: 0834, poster presentation.

• 

Sidler H, Steck R, Knothe Tate ML. Site-Specific Porosity and its Impact on Load-Induced Fluid Movement in Cortical Bone, Transactions of the Orthopaedic Research Society, Chicago, IL, 19 – 22 March, 2006, 31: 1591, poster presentation.

• 

Anderson E, Knothe Tate ML. Effect of Matrix Microporosity, Pericellular Matrix and Cell Process Branching on Periosteocytic Fluid Flow, Transactions of the Orthopaedic Research Society, Chicago, IL, 19 – 22 March, 2006, 31: 1789, poster presentation.

• 

O’Leary J., Knothe Tate, M.L., Knothe, U. Experimental Shock Waves Generate New Bone in Skeletally Mature Rats, commented poster presentation, Transactions of the Orthopaedic Research Society, Chicago, IL, 19 – 22 March, 2006, 31: 0344, commented poster presentation.

Back To Top