MECHBIO

Adam M. Sorkin, M.S.E., P.E. Manager, Experimental Mechanobiology Lab BME Grad Student Office: Room 511, Wickenden building Lab: Room 512, Wickenden Building Phone: (216) 368-6160 Fax: (216) 368-4969 Email: sorkin@case.edu Mail Address: Room 319 Wickenden Building 10900 Euclid Avenue Cleveland, OH 44106-7207
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Research Summary

Bone physiology can be examined on multiple length scales. Results of cell-level studies, typically carried out in vitro, are often extrapolated to attempt to understand tissue and organ physiology. Results of organ- or organism-level studies are often analyzed to deduce the state(s) of the cells within the larger system(s). Although phenomena on all of these scales-cell, tissue, organ, system, organism-are interlinked and contribute to the overall health and function of bone tissue, it is difficult to relate research among these scales. For example, groups of cells in an exogenous, in vitro environment that is well defined by the researcher would not be expected to function similarly to those in a dynamic, endogenous environment, dictated by systemic as well as organismal physiology. Our bone cell mechanobiology research program focuses on developing novel, physiologically relevant methods to model bone and other musculoskeletal models in vitro. We have developed and refined organ culture systems, as well as designed improved cell culture apparatus to more accurately simulate the in vitro environment.

Recent Publications