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MECHBIO

 
 

Experimental and Computational Mechanobiology Laboratories

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Insights into Etiology and Innovative Treatment Modalitiesfor Osteoporosis, Fracture Healing,Osteolysis and Osteonecrosis

OC SyncytiumBridging the gap between medicine and engineering takes teamwork – and the type of faculty and students who play leading roles ranging from basic science discovery to the creation, clinical evolution, and commercialization of new technologies, devices, and therapies. At Case, where the two disciplines meet to create extraordinary results, Melissa Knothe Tate, Ph.D., is the first associate professor of biomedical engineering who holds a joint appointment in Case’s department of mechanical and aerospace engineering. As a mechanical engineer, biologist and biomedical engineer, Dr. Tate notes that the “ultra-subspecialization” in engineering and biomedical science has begun to yield to the establishment of a common scientific culture that promotes understanding of universal or similar mechanisms and survival strategies shared by diverse cells, tissues, organs and organisms. Her favorite example of this is her research team’s multilateral approach to bridge the fundamental gap in understanding physiology “between cells and tissues in the Petri dish and the human organism.” By combining fundamental engineering and biological approaches in innovative experimental models, they hope to unravel the cellular underpinnings of disease and to engineer replacements for tissue destroyed by trauma or disease processes.

Dr. Tate and her research team have developed cutting edge cellular imaging techniques that provide a means to peer into the world of bone cells in the living organism. At the other end of the technological spectrum, the team has applied techniques from stochastic, poroelastic and computational modeling to build in silico, virtual models for simulation of physiological phenomena that are difficult if not impossible to visualize or observe in situ. By approaching an unanswered problem from distinct vantage points, her “MechBio team” (they like to turn around the traditional nomer for biomechanics in order to emphasize the role of the mechanics in the biology) is in fact closing the gap in understanding of cell physiology in real tissues within living organisms. Dr. Tate’s research team is providing a basis for new prophylactic and treatment strategies to promote musculoskeletal health, to manage musculoskeletal disease, and to engineer fully functional musculoskeletal replacement tissues.

-from Research Newsletter, March 2005, CWRU Office of Sponsored research

MechBio News


The lab was well represented by Sarah McBride and Tom Falls at this year's Research ShowCASE. Sarah and Tom presented posters in the graduate student and biomedical engineering student research competitions (pictured below with Nicola Bianchi, right)

 

Melissa Knothe Tate has been selected to participate in the 2007 German-American Frontiers of Engineering Symposium sponsored by the American and German National Academies of Engineering, 26-28 April 2007, Hamburg, Germany (60 international applicants were invited to participate)

January 2006 - Join us in welcoming international scholar Nicola Bianchi from the Università di Pisa, as he joins the lab to complete his thesis work.

December 2006 - Melissa Knothe Tate has publisheda chapter in the new book Bone Tissue Engineering (F. Bronner, C. Farach-Carson, A. Mikos, Ed.) entitled "Multi-scale computational engineering of bones: state of the art insights for the future." (pdf download)

November 2006 - Please join us in congratulating Eric Anderson for successfully defending his doctoral dissertation. Dr. Anderson will remain in the lab as a post-doctoral scholar, working on novel applications funded by the Coulter-Case Translation and Innovation Partnership. Also congratulate graduate student Sarah McBride for being awarded a year-long Case Innovation Incentive Graduate Fellowship to continue her work fluid flow-directed stem cell differentiation.

August 2006 - Melissa Knothe Tate gave the Keynote Lecture for the Cell and Molecular Imaging Session: In Situ Imaging of Bone Cells: Opportunities for Elucidating a Cellular Basis of Bone Disease and Challenges for Clinical Translation, World Congress of Biomechanics, Munich, Germany, 29 July – 5 August 2006. Graduate student Eric Anderson was a finalist in the graduate student papercompetition, awarded for his presentation, Idealization of pericellular fluid space geometry strongly influences the prediction of local stresses imparted by fluid drag on cell surfaces. Eric also received the Case CSE Endowment Sponsored Mentorship Award to support his work and travel to the conference. Mechbio was well represented by the research of numerous members and alumni, including Ulf Knothe, Melissa Knothe Tate, Adam Sorkin, Roland Steck, and Andrea Tami.

May 2006 - Undergraduate students James Ehret, Steven Kreuzer, and Jared O'leary completed their undergraduate coursework have now joined the ranks of Mechbio alumni. James will be joining St. Jude Medical, Steven will be pursuing graduate studies at the University of Texas in Austin, and Jared will begin medical training at Vanderbilt University in the fall.

June 26th, 2005 - Eric Anderson and Steven Kreuzer have represented the group at the 2005 ASME Summer Bioengineering Conferences. Eric's poster, Performance Evaluation Of Tissue Engineering Scaffolds -Development Of A Novel Tool For Optimization Of Fluid Flow & Permeability was a semi-finalist in the M.S. poster competion. Steve's poster, The Presence Of Cellular And Subcellular Structures Dominate Permeability Predictions In The Lacunocanalicular (Pericellular) System Of Bone , was a semifinalist in the B.S. competion.

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