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BIOMEDICAL ENGINEERING
 

Miklos Gratzl, Ph.D.

Associate Professor
Office: Room 520 Wickenden Building
Phone: (216)-368-6589 / 6585 / 6161
Fax: (216)-368-4969
Email: mxg13@case.edu
Mail Address: Room 319 Wickenden Building
10900 Euclid Avenue
Cleveland, OH 44106-7207
Selected links:
• Curriculum Vitae
• Laboratory for Biomedical Sensing >>
• PubMed Citations >>

 

Curriculum Vitae


EDUCATION AND TRAINING

University of Veszprem   BS 1968-71 Chem. Eng.
University of Veszprem   MS 1971-73 Chem. Syst. Eng.
Technical University of Budapest       PhD 1982-86 Electroanal. Chem.

POSITIONS

1985-1987   Senior Research Associate, The Technical University of Budapest
1987-1990   Visiting Assistant Professor, The University of Utah, Salt Lake City, UT
1990-1996   Assistant Professor, Case Western Reserve University, Cleveland, OH
1996-present       Associate Professor, Case Western Reserve University, Cleveland, OH


HONORS

1987-90   Invited Visiting Professorship at the University of Utah, Salt Lake City
1990-present   Organizer and Chair of many BMES and ECS sponsored conference tracks and symposia
1990-present   Executive Committee of the Yeager Center for Electrochemical Sciences
1996   Nominated for the Diekhoff award for excellence in graduate teaching (CWRU)
1999-present   Executive Committee of the Division of Organic and Bioelectrochemistry of the Electrochemical Society
2001-present   International Advisory Board of Sensors (international electronic journal)
2002-present       Editorial Board of the Journal of Mathematical and Physical Sciences(international electronic journal)

PATENTS

  1. Device for optical and electrochemical measurements in microliter size samples. WO9813675, 1998-04-02 and US6043878, 2000-03-28.
  2. Devices and methods for assessing cellular transport for research, drug discovery and testing, clinical diagnoses, and therapy design. WO0073784, 2000-12-07.
  3. Device for precise chemical delivery and solution preparation. WO2004033100, 2004-04-22.
  4. Hydrodynamic micromanipulation of individual cells to patterned attachment sites. WO2004034020, 2004-04-22.
  5. Sliver type autonomous biosensors. WO2004034032, 2004-04-22 and US2004180391, 2004-09-16.
  6. Shape optimization to solve inverse problems and curve/model fitting problems. WO2004034022 and US2004102933, 2004-05-27.
  7. Deposition and detection of zinc and other metals in solution. WO2004109256, 2004-12-16.
  8. Sensor system. WO2005074612, 2005-08-18, and US2005221276, 2005-10-06.
  9. Device for the adjustment of pH of aqueous solutions. WO2006004610, 2006-01-12, and WO2006017000, 2006-02-16.

REVIEWER

Journals: Analytical Chemistry, IEEE Biomedical Engineering Journal, Canadian Journal of Chemistry, Journal of the Electrochemical Society, Langmuir, Journal of Pharmaceutical Sciences, Trends in Analytical Chemistry, Journal of Physical Chemistry, Biotechnology Progress, Journal of Neuroscience Methods, Electroanalysis, Journal of Chemical Biology

Book reviews: Wiley, Dekker

Proposals: National Science Foundation, NIH, Civilian Research and Development Foundation; Department of Defense, U.S. Army Medical Research, and Materiel Command Congressionally Directed Medical Research Program (CDMRP), Florida Department of Health, Petroleum Research Fund


SELECTED PEER REVIEWED PUBLICATIONS (in chronological order)

  1. Kumar G.K., Overholt J.L., Bright G.R., Hui K.Y., Lu H., Gratzl M., Prabhakar N.R.: Release of dopamine and norepinephrine by hypoxia from PC12 cells. Am. J. Phys.: Cell Phys. 274, C1592-1600 (1998)
  2. Yi C., Gratzl M.: Continuous in situ electrochemical monitoring of doxorubicin efflux from sensitive and drug resistant cancer cells. Biophys. J. 75, 2255-2261 (1998)
  3. Yi C., Saidel G., Gratzl M.: Single cell model for simultaneous drug delivery and efflux. Annals of Biomed.Eng. 27, 208-218 (1999)
  4. Gratzl M., Yi C., Lu H., Matsumoto T., Bright G.R.: Fine chemical manipulation of microscopic liquid samples. Part I. Droplet loading with chemicals. Anal. Chem. 71, 2751-2756 (1999)
  5. Lu H., Matsumoto T., Gratzl M.: Fine chemical manipulation of microscopic liquid samples. Part II. Consuming and non-consuming schemes. Anal. Chem. 71, 4896-4902 (1999)
  6. Kashyap R., Gratzl M.: Adjusting the distance of electrochemical microsensors from secreting cell monolayers on the micrometer scale using impedance. Anal. Chem. 71, 2814-2820 (1999)
  7. Lu H., Gratzl M.: Monitoring drug efflux from sensitive and drug resistant single cancer cells with microvoltammetry. Anal. Chem. 71, 2821-2830 (1999)
  8. Lu H., Gratzl M.: Optical detection in microscopic domains. Part I. Monitoring chemical manipulations with absorption spectrometry. Anal. Chem. 72, 1569-1576 (2000)
  9. Tohda K., Lu H., Umezawa Y., Gratzl M.: Optical detection in microscopic domains. Part II. Inner filter effects for monitoring non-fluorescent molecules with fluorescence. Anal. Chem. 73, 2070-2077 (2001)
  10. Cserey A., Gratzl M.: Stationary-state oxidized platinum microsensor for selective and on-line monitoring of nitric oxide in biological preparations. Anal. Chem. 73(16), 3965-3974 (2001)
  11. Tohda K., Gratzl M.: A microscopic, continuous, optical monitor for interstitial electrolytes and glucose. J. of Chem. Phys. and Phys. Chem. (CPC), 4 (2) 155-160 (2003)
  12. Yoshida M., Tohda K., Gratzl M.: Hydrodynamic micromanipulation of individual cells onto patterned attachment sites on bioelectromechanical system chips. Anal.Chem. 75(17), 4686-4690 (2003)
  13. Yoshida M., Tohda K., Gratzl M.: Optical detection in microscopic domains. 3. confocal analysis of fluorescent amphiphilic molecules. Anal. Chem., 75(22), 6133-6140 (2003)
  14. Tohda K., Gratzl M.: Microscopic, continuous, optical monitor for interstitial electrolytes and glucose. J. Chem. Phys. Chem. 4, 155-160 (2003)
  15. Nair S., Gratzl M.: Assessing transport at live cell preparations: a case study on anomalies of deconvolution via discrete Fourier transform. Trends in Anal. Chem. 23(6), 459-467 (2004)
  16. Nair S., Gratzl M.: Deconvolution of concentration recordings at live cell preparations via shape error opti-mization. Anal. Chem., 77(9), 2875-2881 (2005)
  17. Shetty G., Syed N., Tohda K., Gratzl M.: Hydrodynamic electrochemistry in 20 μL drops in the rotating sample system. Anal. Sci. 21(10), 1155-1160 (2005)
  18. Tohda K., Gratzl M.: Micro-miniature Autonomous Optical Sensor Array for Monitoring Ions and Metabolites 1: Design, Fabrication, and Data Analysis. Anal. Sci. 22(3), 383-388 (2006)
  19. Tohda K., Gratzl M.: Micro-miniature Autonomous Optical Sensor Array for monitoring ions and metabolites 2: Color Response to pH, K+, and Glucose. Anal.Sci. 22(7): 937-941 (2006)
  20. Oruganti P., Gratzl M.: Rate-limiting Hydrodynamic Resistance for Controlled Reagent Delivery for Labora-tory Solution Preparation. Anal. Chem. 79(6): 2541-2545 (2007)
  21. Gratzl M.: Micro-electrochemistry for biomedical applications. In: Recent advances in analytical electro-chemistry, invited chapter; ISBN: 978-81-7895-274-1, 251-277 (2007)
  22. Nair S., Kashyap R, Laboisse C.L., Hopfer U., Gratzl M.: Time resolved secretion of Chloride from A Mono-layer of Mucin Secreting Epithelial Cells. Eur. Biophy. J. 37(4): 411-419 (2008)
  23. Sheth D., Suresh G., Yang J., Ladas T, Zorman C.A., Gratzl M.: MEMS Device to Monitor Biological Oxy-gen Uptake at Arrays of Single Cells and Small Clusters. Electroanalysis. 20(6): 627-634 (2008)
  24. Kao LT., Hsu H., Gratzl M.: Reagentless pH-stat for Microliter Fluid Specimens. Anal. Chem. ASAP Article, 10.1021/ac800161y. Web Release Date: April 29, 2008

RESEARCH SUPPORT

Ongoing Research Support

Reagentless pH-stat for microliter biological samples. PI: M. Gratzl; NSF: (August 2004 – July 2009)

Sliver sensor for minimally invasive in vivo monitoring of glucose. PI: M. Gratzl; Coulter-Case Transla-tional Research and Innovation Partnership Program (April 2007 – March 2009)

Completed Research Support in past 5 years

Microminiature sensing platform for painless, infection-free, and continuous in vivo monitoring of glucose and basic electrolytes of astronauts, requiring negligible power, no clinical expertise, and fully compatible with telemetry. PI: M. Gratzl; NASA: (May 2002-April 2005)

Development of Microdiagnostics for in vitro and in vivo applications. PI: M.Gratzl; Vision Sensors/VVF fund; (Aug 2002-Aug 2005)

Lead diagnostics with a microfabricated disposable tester. CWRU PI: M.Gratzl; NIH/SBIR: Phase I, year 1 (started in November 2002)

Exploratory study on feasibility of the optode bead technology for cardiac applications. Guidant Inc. (August – November 2005)

This page was last modified May 02, 2008