BIOMEDICAL ENGINEERING

Horst von Recum , Ph.D. Assistant Professor Office: 220 Wickenden Phone: (216)368-5513 Fax: (216)368-4969 Email: hav1@case.edu Mail Address: Room 309 Wickenden Building 10900 Euclid Avenue Cleveland, OH 44106-7207
Selected links: • Department of Biomedical Engineering • Center for Delivery of Molecules and Cells • Curriculum Vitae

Research Summary

The research in our laboratory focuses on novel platforms for the delivery of molecules and cells. In the molecular delivery projects we are examining novel degradable polymer platforms for delivery of therapeutic agents for HIV therapies, wound dressings, ocular disease and localized chemotherapy. We are also investigating the use of novel stimuli-responsive polymers for use in gene, and drug delivery. These polymers can allow binding and loading under one condition, and release or expression under another condition.

The cellular delivery projects are examining using directed differentiation to produce tissue engineered constructs from stem cell sources. Stem cells show great promise as a therapeutic tool due to there unlimited replication potential and their plasticity, or capacity to become many different cell types. Better control of differentiation and selection, will allow for rapid expansion of high purity differentiated cells suitable for tissue engineering, toxicology and pharmacology, as well as cellular modeling, without the need for isolating cells from primary sources.

Recent Publications

* contributed equally to this work