|
|
Gerald M. Saidel, Ph.D.
Professor, Department of Biomedical Engineering
Director, Center for Modeling Integrated Metabolic Systems
| Office: |
Room 410 Wickenden Building |
| Phone: |
(216)-368-4066 |
| Fax: |
(216)-368-4969 |
| Email: |
gerald.saidel@case.edu |
| Mail Address: |
Room 309 Wickenden Building
10900 Euclid Avenue
Cleveland, OH 44106-7207 |
|
|
|
Research Summary
| • |
Biomedical mass transport, heat transport, metabolism: diagnosis and therapy |
| |
| • |
Mathematical modeling, simulation, parameter estimation, optimal experiment design |
| |
| • |
Cellular metabolic dynamics in tissue, organ, and whole body systems |
| |
| • |
Histological and model analysis of tissue adaptation and cellular responses to in vivo chronic heating |
| |
| • |
Thermal modeling of tissue ablation by RF or laser heating with MRI guidance for minimally invasive tumor destruction |
| |
| • |
controlled-release drug delivery from polymeric devices implanted in tissue for targeted destruction of cancer cells |
| |
Recent Publications
| • |
Salinas C, Muzic RF, Saidel GM, Validity of model approximations for receptor-ligand kinetics in nuclear medicine. Med. Phys. 34:1693-1703, 2007. |
| |
| • |
Wang F, Saidel GM, Gao J, Mechanistic model of controlled drug release from polymer millirods: effects of excipients and complex binding, J. Controlled Release 119:11-120, 2007. |
| |
| • |
Zhou H, Saidel GM, Cabrera ME, Multi-organ system model of O2 and CO2 transport during isocapnic and poikilocapnic hypoxia. Resp. Physiol. & Neurobiol. 156:320–330, 2007. |
| |
| • |
Salinas C, Muzic RF, Ernsberger P, Saidel GM, Robust experiment design for estimating myocardial beta adrenergic receptor concentration using PET. Med. Phys. 34:151-165, 2007. |
| |
| • |
Saidel GM, Cabrera ME, Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control. Ann. Biomed. Eng. 35:69-90, 2007. |
| |
| • |
Lai N, Dash RK, Nasca MM, Saidel GM, Cabrera ME, Relating pulmonary oxygen uptake to muscle oxygen consumption at exercise onset: in vivo & in silico studies. European J Appl. Physiol. 97:380-394, 2006. |
| |
| • |
Zhou L, Stanley WC, Saidel GM, Yu X, Cabrera ME, Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies. J Physiol (London) 569:25–937, 2005. |
| |
| • |
Lee K, Saidel GM, Penn MS, Macromolecular transport in the arterial wall: alternative models for estimating barriers. Ann. Biomed. Eng. 33:1491-1503, 2005. |
| |
| • |
Lee K, Forudi F, Saidel GM, Penn MS, Alterations in internal elastic lamina permeability as a function of age and anatomical site precede lesion development in apolipoprotein E-null mice. Circ. Res. 97:450-456, 2005. |
| |
| • |
Zhou L, Salem JE, Saidel GM, Stanley WC, Cabrera ME, Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to subdomain during ischemia, Am. J. Physiol. 288:H2400-2411, 2005. |
|
|
