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Miklos Gratzl, Ph.D.
Associate Professor
| Office: | Room 448 Wickenden Building |
| Phone: | (216)-368-6589 / 6585 |
| Fax: | (216)-368-4969 |
| Email: | mxg13@case.edu |
| Mail Address: | Room 319 Wickenden Building
10900 Euclid Avenue
Cleveland, OH 44106-7207 |
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Curriculum Vitae
EDUCATION AND TRAINING
• University of Veszprem BS 1968-71 Chem. Eng.
• University of Veszprem MS 1971-73 Chem. Syst. Eng.
• Technical University of Budapest PhD 1982-86 Electroanal. Chem.
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POSITIONS
| | Instructor and Research Assistant, The Technical University of
Budapest |
| | Research Associate, Ecole Centrale des Arts et Manufactures, Paris,
France |
| | Research Associate, The Technical University of Budapest |
| | Research Associate, Eidgenössische Technische Hochschule,
Zürich, Switzerland |
| | Research Associate, The Technical University of Budapest |
| | Research Associate, The University of Florida, Gainesville, FL |
| | Research Associate, The Technical University of Budapest |
| | Research Associate, The University of North Carolina, Chapel Hill,
NC |
| | Senior Research Associate, The Technical University of Budapest |
| | Visiting Assistant Professor, The University of Utah, Salt Lake
City, UT |
| | Assistant Professor, Case Western Reserve University, Cleveland,
OH |
| | Associate Professor, Case Western Reserve University, Cleveland,
O |
HONORS
| | Scholarship of the French Research Council to conduct research at the
Ecole des Arts et Manufactures, Paris (6 months) |
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Scholarship of the International Scientific Exchange Program to
conduct research at the Swiss Federal Institue of Technology (ETH), Zürich, Switzerland |
| | Award of the "Best Scientific Paper of the Year" in 1984
by the Hungarian Journal of Chemistry (see item 4 in the List of Articles) |
| | Invited Visiting Professorship at the University of Utah, Salt Lake
City |
| | Many invited lectures and seminars at conferences, universities,
research institutions and companies |
| | Member of the Biomedical Engineering Society, Member of the
Electrochemical Society |
| | Organizer and Chair of many BMES and ECS sponsored conference
tracks and symposia |
| | Executive Committee of the Yeager Center for Electrochemical
Sciences |
| | Nominated for the Diekhoff award for excellence in graduate teaching
(CWRU) |
| | Executive Committee of the Division of Organic and Bioelectrochemistry
of the Electrochemical Society |
| | One year sabbatical leave awarded with FULL salary for the entire
year from CWRU, spent at European universities |
| | International Advisory Board of Sensors (international electronic
journal) |
| | Editorial Board of the Journal of Mathematical and Physical
Sciences(international electronic journal) |
| | Invited feature articles such as Tohda & Gratzl, 2003, J.Chem.Phys.Phys.Chem. (the cover of the journal was also featuring this work); Nair & Gratzl, 2004, Trends in Anal.Chem.; and a number of earlier articles |
PATENTS
- Device for optical and electrochemical measurements in microliter size samples.
US patent # 6,043,878 (28 March 2002) This patent application was also filed
internationally at the same time (European Union, Japan)
- Device and methods for assessing cellular transport for research, drug
discovery and testing, clinical diagnoses, and therapy design. Filed in April
2000, both as a US patent and internationally.
- Sliver type autonomous biosensors. Filed October 2003 both as a US patent an internationally.
- Device for precise chemical delivery and solution preparation. (ibid.)
- Hydrodynamic manipulation of individual cells to patterned attachment sites. (ibid.)
- Shape optimization to solve inverse problems and curve/model fitting problems. (ibid.)
REVIEWER
- Journals: Analytical Chemistry, IEEE Biomedical Engineering Journal, Canadian
Journal of Chemistry, Journal of the Electrochemical Society, Langmuir, Journal
of Pharmaceutical Sciences, Trends in Analytical Chemistry, Journal of Physical
Chemistry, Biotechnology Progress, Journal of the American Chemical Society
- Book reviews: Wiley, Dekker
- Proposals: National Science Foundation, NIH, Civilian Research and Development
Foundation; Department of Defense, U.S. Army Medical Research, and Materiel
Command Congressionally Directed Medical Research Program (CDMRP)
SELECTED PEER REVIEWED PUBLICATIONS
(in chronological order from 100 peer-reviewed journal articles)
- Váradi M., Gratzl M., Pungor E.: Turbulent Hydrodynamic Voltammetry,
Part II. Investigations of Turbulence Frequency in a Hydrodynamic Cell. Anal.
Chim. Acta, 83, 1-8 (1976)
- Gratzl M., Rakiás F., Horvai Gy., Tóth K., Pungor E.: Effect
of pH on the Response of a Cyanide Ion-Selective Electrode. Anal. Chim. Acta,
102, 85-90 (1978)
- Bates R.G., Dickson A., Gratzl M., Hrabéczy-Páll A., Lindner
E., Pungor E.: Determination of Mean Activity Coefficients with Ion-Selective
Electrodes. Anal. Chem., 55, 8, 1275-1280 (1983)
- Gratzl M., Pólos L., Tóth K., Pungor E., Ebel M.F., Ebel
H., Zuba G., Wernisch J.: Reactive Ion-Selective Electrodes, Part I. Surface
Study of Precipitate Based Cyanide Electrodes. Magy. Kémiai Foly.,
90, 487-497 (1984)
- Gratzl M., Lindner E., Pungor E.: Theoretical Interpretation of Transient
Signals Obtained with Precipitate-Based Ion-Selective Electrodes in the Presence
of Interfering Ions. Anal. Chem., 57, 1506-1511 (1985)
- Gratzl M., Hsu Duan-Fu, Riley A.M., Janata J.: Electrochemically Deposited
Polythiophene. Part I: Ohmic Drop Compensation and the Polythiophene Paradox.
J. Phys. Chem., 94, 5973-5981 (1990)
- Gratzl M., Yi C.: Diffusional Microtitration: Acid/Base Titrations in Pico-
and Femtoliter Samples. Anal. Chem., 65, 2085-2088 (1993)
- Yi C., Gratzl M.: Diffusional Microtitration: Reagent Delivery by a Diffusional
Microburet into Microscopic Samples. Anal. Chem., 66, 1976-1982 (1994)
- Hui K.Y., Gratzl M.: Anomalies of Convolutional Smoothing and Differentiation.
Anal. Chem. 68, 1054-57 (1996)
- Diefes R.S., Hui K.Y., Dudik L., Liu C.C., Gratzl M.: Sample/Reagent Adsorption
on Alumina vs. Pyrex Substrates of Microfabricated Electrochemical Sensors.
Sensors and Actuators B, Chem., SNB030/2, 133-136 (1996)
- Yi C., Huang D.J., Gratzl M.: Complexometric Determination of Metal Ions
by Microscopic Diffusional Titration. Anal. Chem. 68, 1580-1584 (1996)
- Xie H., Gratzl M.: Diffusional Microtitration of Metal Ions in 1-20 Microliter
Samples. Anal.Chem. 68, 3665-3669 (1996)
- Hui Y.K., Gratzl M.: Diffusional Microtitration of 20 Microliter Samples
with Optical Indication. Anal. Chem. 69, 695-698 (1997)
- Cserey A., Gratzl M.: Rotating sample system: an equivalent of a rotating
electrode for microliter samples. Anal. Chem. 69, 3687-3692 (1997)
- Kashyap R., Gratzl M.: Electrochemistry in microscopic domains. Part I.
The electrochemical cell and its voltammetric and amperometric response. Anal.
Chem. 70, 1468-1476 (1998)
- Kumar G.K., Overholt J.L., Bright G.R., Hui K.Y., Lu H., Gratzl M., Prabhakar
N.R.: Release of dopamine and norepinephrine by hypoxia from PC12 cells. Am.
J. Phys.: Cell Phys. 274, C1592-1600 (1998)
- Yi C., Gratzl M.: Continuous in situ electrochemical monitoring of doxorubicin
efflux from sensitive and drug resistant cancer cells. Biophys. J. 75, 2255-2261
(1998)
- Yi C., Saidel G., Gratzl M.: Single cell model for simultaneous drug delivery
and efflux. Annals of Biomed.Eng. 27, 208-218 (1999)
- Gratzl M., Yi C., Lu H., Matsumoto T., Bright G.R.: Fine chemical manipulation
of microscopic liquid samples. Part I. Droplet loading with chemicals. Anal.
Chem. 71, 2751-2756 (1999)
- Lu H., Matsumoto T., Gratzl M.: Fine chemical manipulation of microscopic
liquid samples. Part II. Consuming and non-consuming schemes. Anal. Chem.
71, 4896-4902 (1999)
- Kashyap R., Gratzl M.: Adjusting the distance of electrochemical microsensors
from secreting cell monolayers on the micrometer scale using impedance. Anal.
Chem. 71, 2814-2820 (1999)
- Lu H., Gratzl M.: Monitoring drug efflux from sensitive and drug resistant
single cancer cells with microvoltammetry. Anal. Chem. 71, 2821-2830 (1999)
- Lu H., Gratzl M.: Optical detection in microscopic domains. Part I. Monitoring
chemical manipulations with absorption spectrometry. Anal. Chem. 72, 1569-1576
(2000)
- Tohda K., Lu H., Umezawa Y., Gratzl M.: Optical detection in microscopic
domains. Part II. Inner filter effects for monitoring non-fluorescent molecules
with fluorescence. Anal. Chem. 73, 2070-2077 (2001)
- Cserey A., Gratzl M.: Stationary-state oxidized platinum microsensor for
selective and on-line monitoring of nitric oxide in biological preparations.
Anal. Chem. 73(16), 3965-3974 (2001)
- Tohda K., Gratzl M.: A microscopic, continuous, optical monitor for interstitial
electrolytes and glucose. J. of Chem. Phys. and Phys. Chem. (CPC), 4 (2) 155-160
(2003)
- Yoshida M., Tohda K., Gratzl M.: Hydrodynamic micromanipulation of individual
cells onto patterned attachment sites on bioelectromechanical system chips.
Anal.Chem. 75(17), 4686-4690 (2003)
- Yoshida M., Tohda K., Gratzl M.: Optical detection in microscopic domains.
3. confocal analysis of fluorescent amphiphilic molecules. Anal. Chem., 75(22),
6133-6140 (2003)
- Nair S., Gratzl M.: Assessing transport at live cell preparations: a case study on anomalies of deconvolution via discrete Fourier transform. TRAC, June 2004.
RESEARCH SUPPORT
Support has been obtained in the past years from NIH, NSF, The Whitaker
Foundation, The Cystic Fibrosis Foundation, NASA, and private sources, to fund
research projects in the Laboratory for Biomedical Sensing, with Dr Gratzl as
the Principal Investigator. As Co-Principal Investigator or Co – Investigator,
further grants were obtained, including Program Grants, Instrumentation Grants,
and Training Grants.
Current grants include NASA and NSF grants, an NIH-SBIR grant, and industrial funding.
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