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Miklos Gratzl, Ph.D.
Associate Professor
| Office: |
Room 425 Wickenden Building |
| Phone: | (216)-368-6589 / 6585 |
| Fax: | (216)-368-4969 |
| Email: | mxg13@case.edu |
| Mail Address: |
Room 309 Wickenden Building
10900 Euclid Avenue
Cleveland, OH 44106-7207 |
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Research Summary
Development and biomedical application of chemical sensing schemes is the focus of my laboratory. Diagnostics in 1-20 microliter body fluids and other samples is performed using micro fabricated electrochemical and optical sensors and an electrochemical micro-pH-stat. We also developed an equivalent of rotating electrode for microliter samples, called the rotating sample system. For cellular research, a diffusional microburet has been developed to continuously deliver reagents and drugs into single live cells. Fluorescence microscopy is employed to quantitate intracellular accumulation. Efflux is measured with a carbon fiber based electrochemical microsensor that can detect Adriamycin, a cancer drug, extruded from cells at very low concentrations. Neurochemical studies as well as measurements at epithelial cell layers are also performed with different microscopic sensing schemes.
Recent Publications
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Oruganti P, Gratzl M, Rate limiting hydrodynamivc resistance for controlled reagent delivery. Anal. Chem., in press. |
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Kao LT, Shetty G, Gratzl M, Electrochemical pH-stat for microliter fluid specimens. J. ECS, 2006. |
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Tohda K, Gratzl M, Micro-miniature autonomous optical sensor array for monitoring ions and metabolites. Anal. Sci. 22 (7) 937-941 (2006) |
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Tohda K, Gratzl M, Micro-miniature autonomous optical sensor array for monitoring ions and metabolites. Part 1. Design, fabrication, and data analysis. Anal. Sci., 22, 383-388 (2006) (article featured on cover of journal, and designated as "hot" article). |
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Shetty G, Syed N, Tohda K, Gratzl M, Hydrodynamic electrochemistry in 20 mL drops in the rotating sample system. Anal. Sci. 21 (10), 1155-1160 (2005) (article featured on cover of journal). |
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Nair S, Gratzl M, Deconvolution of concentration recordings at live cell preparations via shape error optimization. Anal. Chem., 77(9), 2875-2881 (2005). |
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