| Steven
Eppell, Ph.D.
Associate Professor
| Office: |
Room 203 Wickenden Building |
| Phone: |
(216)-368-4067 |
| Fax: |
(216)-368-4969 |
| Email: |
sje@case.edu |
| Mail Address: |
Room 309 Wickenden Building
10900 Euclid Avenue
Cleveland, OH 44106-7207 |
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Research Summary
The focus of research in my laboratory
in on orthopedic biomaterials. Fixation of implants (a
biochemical phenomenon) and stress shielding (a biomechanical
phenomenon) are two of the major clinical problems associated
with currently available biomaterials. We are interested
in taking a first principles approach to understanding
molecular interactions leading to biochemical and biomechanical
function of cartilage and bone. Our emphasis is on analysis
of these tissues at the sub-molecular level which is
accomplished by the development and use of nanoscale
instrumentation. Currently we are applying these techniques
to the study of collagens and the fundamental mineral
units found in bone. The results of these experiments
will guide us away from the use of homogenous materials
(like the clinically popular Ti and Co based alloys)
and toward more sophisticated hierarchical composites.
Recent Publications
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Katz JL, Misra A, Spencer P, Wang Y, Bumererraj S, Nomura T, Eppell SJ, Tabib-Azar M, Multiscale mechanics of hierarchical structure/property relationships in calcified tissues and tissue/material interfaces, Materials Science and Engineering, In Press . |
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Liu Z, Smith BN, Kahn H, Ballarini R, Eppell SJ. Mechanical Testing of Hydrated Collagen Nanofibrils Using MEMS Technology, Sixth IEEE Conference on Nanotechnology, 17-20 July 2006, Cincinnati, Ohio, USA. IEEE catalog number 06TH8861C, ISBN 1-4244-0078-3, library of congress 2005937117, 2006. |
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Eppell SJ, Smith BN, Kahn H, Ballarini R, Nano Measurements With Micro Devices: mechanical properties of hydrated collagen fibrils, Journal of the Royal Society Interface, 3, No. 6, pp. 117-121 (2006). |
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DiLisi GA, Eppell SJ and Upton J, Hierarchical Learning Ensembles: Team-Building for Undergraduate Scientists and Engineers, J. of College Science Teaching, XXXV, No. 5, pp.21-25 (2006). |
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Vasanji A, Ghosh PK, Graham LM, Eppell SJ, Fox PL, Polarization of plasma membrane microviscosity during endothelial cell migration, Dev Cell. 6, No. 1, pp. 29-41 (2004). |
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Todd BA and Eppell SJ, Probing the Limits of the Derjaguin Approximation with Scanning Force Microscopy, Langmuir, 20, No. 12, pp. 4892-4897 (2004). |
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