| Dominique
M. Durand
Professor
| Office: |
Room 112 Wickenden Building |
| Phone: |
(216)-368-3974 |
| Fax: |
(216)-368-4872 |
| Email: |
dominique.durand@case.edu |
| Mail Address: |
Wickenden 309
Department of Biomedical Engineering
Neural Engineering Center
Case Western Reserve University
Cleveland OH |
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Neural Engineering is a new discipline at
the interface between engineering and neuroscience. Neural
Engineering research in my laboratory combines computational
neuroscience, engineering and electrophysiology to solve
problems in the central and peripheral nervous systems.
In the CNS, the mechanisms of synchronization
of neuronal activity during epilepsy are investigated
using in-vitro brain slice preparations, in-vivo multiple
electrode recording and computer models. The interaction
between applied currents and neuronal tissue are studied
to determine the feasibility of controlling seizures
in patients with epilepsy.
In the peripheral nervous system, novel
nerve electrodes are being developed capable of stimulating
and recording neuronal activity selectively. This neural
interfacing methodology is applied to the hypoglossal
nerve to restore patency in the airways in patients with
obstructive sleep apnea and to design neural prostheses
for patients with spinal cord injury and stroke. Computer
simulations of both neurons and volume conductors are
used in conjunction with the experiments for the quantitative
analysis of neural systems and to design new electrodes
for interfacing with the nervous system.
Recent Publications
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Durand DM, Neural Engineering: a new discipline for analyzing and interacting with the nervous system, Methods of Information in Medicine, In Press, 2006. |
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Leventhal DE and Durand DM, Chronic histological effects of the flat interface nerve electrode, 3:102-113, J. of Neural Engineering, 2006. |
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Feng Z and Durand DM, Effects of Potassium Concentration on Firing Patterns of Low-Calcium Epileptiform Activity in Anesthetized Rat Hippocampus --- Inducing Persistent Spike Activity, 47(4):727-36, Epilepsia, 2006. |
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Park EH and Durand DM, Role of Potassium Lateral Diffusion in Non-synaptic Epilepsy: A Computational Study, Journal of Theoretical Biology, 238: 666-682, 2006. |
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Lertmanorat Z and Durand DM, Electrode array for reversing the recruitment order of peripheral nerve stimulation: Experimental studies, Annals of Biomedical Engineering, Jan;34(1):152-60, 2006. |
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Huang J, Sahin M and Durand DM, Dilation of the oropharynx via selective stimulation of the hypoglossal nerve, Journal of Neural Engineering, 2 (2005) 73–80, 2005. |
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Feng Z and Durand DM, Propagation of low-calcium non-synaptic induced epileptiform activity to the contralateral hippocampus in-vivo, Brain Research, 1055 (1-2):25-35, 2005. |
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Yoo PB and Durand DM, Effects of Selective Hypoglossal Nerve Stimulation on Canine Upper Airway Mechanics, Journal of Applied Physiology, 99(3):937-43, 2005. |
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Yoo PB and Durand DM, Selective recording of the canine hypoglossal nerve using a multi-contact flat interface nerve electrode, IEEE Transactions on Biomedical Engineering, 52(8):1461-9, 2005. |
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Kumar A, Han Y, Dell´Osso LF, Durand DM and Leigh RJ, Directional asymmetry during combined saccade-vergence movements, J. Neurophysiology, 93:2797-2808, 2005. |
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Feng Z and DM Durand, Decrease in Synaptic Transmission Can Reverse the Propagation Direction of Epileptiform Activity in Hippocampus in vivo, J. Neurophysiology, 93:1158-1164, 2005. |
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