Harihara
Baskaran
Assistant Professor
| Office: |
A.W Smith Building Room 111A |
| Phone: |
(216) 368-1029 |
| Fax: |
|
| Email: |
hxb35@case.edu |
| Mail Address: |
Room 309 Wickenden Building
10900 Euclid Avenue
Cleveland, OH 44106-7207 |
|
|
|
Research Summary
Microvascular Tissue Engineering: Tissue
engineering has the potential to revolutionize healthcare.
A significant challenge in tissue engineering is to overcome
substrate mass transfer limitations, which if ignored
can result in a product that will not function adequately.
The main goal of this research is to design and build
microvascular flow analogs that can be used to overcome
nutrient limitations in tissue-engineered products.
Cell Transport: Cell transport is important
in several physiological and pathological processes such
as inflammation, embryogenesis, cancer metastasis and
wound healing. Several mechanisms of cell transport have
been identified: passive transport through random diffusion
and active transport via convection and mechanisms such
as chemotaxis, chemokinesis, and haptotaxis. The main
goal of this research is to understand various mechanisms
of cell transport and to modulate the growth of cell
monolayers.
Recent Publications
| • |
H. Baskaran*, Noo Li Jeon*, S. W. Dertinger,
L. Van De Water, G. M. Whitesides, and M. Toner. "Neutrophil
Chemotaxis in Linear and Complex Gradients of Il-8
Formed in a Microfabricated Device", Nature Biotechnology,
20, 826-830, 2002. |
| |
| • |
H. Baskaran*, P. Roy*, A. W. Tilles, M. L. Yarmush,
and M. Toner. "Analysis of Oxygen Transport to Hepatocytes
in a Flat-Plate Microchannel Bioreactor", Annals
of Biomedical Engineering, 29, 947-955, 2001. |
| |
| • |
A. W. Tilles, H. Baskaran, P. Roy, M. L. Yarmush,
and M. Toner. "Effects of Oxygenation and Flow on
the Viability and Function of Rat Hepatocytes Co-Cultured
in a Microchannel Flat-Plate Bioreactor", Biotechnology
and Bioengineering, 73, 379-89, 2001. |
| |
| • |
H. Baskaran, V. Nodelman, and J.S. Ultman. "Gas-Liquid
Desorption Through Blind-Ended Microporous Hollow
Fibers for an Intravascular Artificial Lung", Industrial
and Engineering Chemistry, 37, 4142-51, 1998. |
| |
| *Co-First Authors |
|
|
