James
Basilion, Ph.D.
Associate Professor
| Office: |
Room 3531 Wolstein Building |
| Phone: |
(216) 368-0840 |
| Fax: |
(216) 368-4969 |
| Email: |
james.basilion@case.edu |
| Mail Address: |
Room 319 Wickenden Building
10900 Euclid Avenue
Cleveland, OH 44106-7207 |
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Research Summary
Molecular imaging, defined as the in
vivo characterization of biological processes at
the cellular and molecular level, is an attempt to
image the molecular make-up of the macrofeatures currently
visualized using "classical" diagnostic imaging
techniques. Classically, detection of malignant tumor
cells in a background of normal or hyperplastic benign
tissue is often based on differences in physical properties
between tissues, which are frequently minimal, resulting
in low contrast resolution
My laboratory concentrates on research related to the
development and application of Molecular Imaging technologies.
Specifically we are interested in designing novel imaging
tools to image individual and multiple molecular markers
of disease. We believe that imaging tissues based on
the underlying molecular rather than macromolecular differences
will result in a substantial increase in the sensitivity
and specificity of medical imaging. Some areas of active
research include defining "molecular signatures" of
disease, developing paradigms to image multiple markers
of disease simultaneously, developing methods to image
intracellular disease markers in breast cancer, and developing
molecular imaging technologies that allow for intraoperative
assessment of disease progression.
Recent Publications
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Sato, F., Fukuhara, H., and Basilion,
J.P. Effects of Hormone Deprivation and 2-Methoxyestradiol
Combination Therapy on Hormone Dependent Prostate
Cancer In Vivo. In press Neoplasia, 2005. |
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Tsourkas, A., Newton, G., Perez, J., Basilion,
J.P., and Weissleder, R. Detection of Peroxidase-Mediated
Dityrosine Formation with Enhanced Yellow Fluorescent
Protein. Anal Chem. 2005, 77(9):2862-7. |
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Savellano, D.H., Bos, E., Blondet,
C., Sato, F., Abe, T., Josephson, L., Weissleder,
R., Gaudet, J., Sgroi, D., Peters, P.J., and Basilion,
J.P. The Transferrin Receptor: A Potential Molecular
Imaging Marker for Human Cancer. Neoplasia, 2003
5(6): 495-506. |
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Abe, T., Terada, K., Wakimoto, H.,
Bookstein, R., Basilion, J.P., and Chiocca,
E.A. PTEN decreases in vivo vascularization of experimental
gliomas in spite of pro-angiogenic stimuli. Cancer
Research, 2003 May 1;63(9):2300-5. |
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Ichikawa, T., Hogemann, D., Saeki,
Y., Tyminski, E., Terada, K., Weissleder, R., Chiocca,
E.A., and Basilion, J.P. MR Imaging of Transgene
Expression: Correlation to Therapeutic Gene Expression.
Neoplasia, 2002, vol 4, No. 6, pp. 523-530. |
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Weissleder, R., Moore, A.,Ph.D., Mahmood-Bhorade,
U., Benveniste, H. Chiocca, E.A., Basilion, J.P. High
resolution in vivo imaging of transgene expression.
Nature Medicine, 2000, 6:351-355. |
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