Eben Alsberg, Ph.D.
Assistant Professor
| Office: |
Room 204 Wickenden Building |
| Phone: |
(216)368-6425 |
| Fax: |
(216)368-4969 |
| Email: |
eben.alsberg@case.edu |
| Mail Address: |
Room 309 Wickenden Building
10900 Euclid Avenue
Cleveland, OH 44106-7207 |
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Research Summary
Our laboratory focuses on engineering functional biologic replacements to repair damaged or diseased tissues in the body. We use the complex signals that are implicated in tissue morphogenesis, repair, and homeostasis as a template for the development of innovative biomaterials for tissue regeneration. Through the precise temporal and spatial presentation of soluble bioactive factors, mechanical forces, and biomaterial physical and biochemical properties, we aspire to create microenvironments that regulate cell gene expression and new tissue formation. Some areas of active investigation include controlling stem cell differentiation, delivering bioactive factors sequentially, developing spatially patterned constructs, understanding cell-cell interactions, and determining mechanical influences on cell function.
Recent Publications
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Solorio LD, Fu AS, Hernandez-Irizarry R, Alsberg E: Chondrogenic differentiation of human mesenchymal stem cell aggregates via controlled release of TGF-b1 from incorporated polymer microspheres. Journal of Biomedical Materials Research-A (accepted-in press). |
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Krebs MD, Salter E, Chen E, Sutter KA, Alsberg E: Calcium phosphate-DNA nanoparticle gene delivery from alginate hydrogels induces in vivo osteogenesis. Journal of Biomedical Materials Research-A (accepted-in press). |
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Alsberg E, Feinstein E, Joy MP, Prentiss M, Ingber DE: Magnetically-guided self-assembly of fibrin matrices with ordered nanoscale structure for tissue engineering. Tissue Engineering, 12(11): 3247-3256, 2006. (Chosen for cover) |
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Alsberg E, von Recum HA, Mahoney MJ. Environmental cues to guide stem cell fate decision for tissue engineering applications. Expert Opinion on Biological Therapy, 6(9):847-866, 2006. |
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Lee KY*, Alsberg E*, Hsiong S, Mooney DJ: Nanoscale adhesion ligand organization regulates osteoblast proliferation and differentiation. Nanoletters, 4(8): 1501-1506, 2004. *Shared first authorship. |
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Alsberg E, Moore K, Huang S, Polte T, Ingber DE. The mechanical and cytoskeletal basis of lung morphogenesis. In: Massaro D, et al., eds. Lung Development and Regeneration. Vol. 190. New York, NY: Marcel Dekker, Inc., 2004: 247-274. |
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Simmons CA*, Alsberg E*, Hsiong S, Kim WJ, Mooney DJ: Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone, 35(2): 562-569, 2004. *Shared first authorship. |
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Alsberg E, Kong HJ, Hirano Y, Smith MK, Albeiruti A, Mooney DJ: Regulating bone formation via controlled scaffold degradation. Journal of Dental Research, 82(11): 903-908, 2003. |
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Alsberg E, Anderson KW, Albeiruti A, Rowley JA, Mooney DJ: Engineering growing tissues. Proceedings of the National Academy of Sciences, 99(19): 12025-12030, 2002. |
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Alsberg E, Anderson KW, Albeiruti A, Franceschi RT, Mooney DJ: Cell-interactive alginate hydrogels for bone tissue engineering. Journal of Dental Research, 80(11): 2025-29, 2001. |
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Alsberg E, Hill EE, Mooney DJ: Craniofacial tissue engineering. Critical reviews in oral biology and medicine, 12(1): 64-75, 2001. |
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