Graduate BME Courses
EBME
401. Bioelectric
Phenomena (3)
Models of excitable cells and membranes. Neural and Cardiac
action potentials. Propagation of excitation. Bioelectric
sources, volume conductor fields. Electric Field interaction
with excitable tissue.
Prerequisites: MATH
224 (or equivalent), EBME 201 (or
equivalent), ENGR
210.
EBME
402. Muscles,
Biomechanics, and Control of Movement (4)
Quantitative and qualitative descriptions of the action
of muscles in relation to human movement. Introduction
to rigid body dynamics and dynamics of multi-link systems
using Newtonian and Langrangian approaches. Muscle models,
receptors and reflexes with application to control of
multi-joint movement. Forward and inverse dynamics of
multi-joint, muscle driven systems. Dissection, observation
and recitation in the anatomy laboratory with supplemental
lectures concentrating on kinesiology and muscle function.
Prerequisites: EMAE
181 (or equivalent).
EBME
403. Biomedical
Transducers (3)
Analysis and design of transducers: optical, photo-electric,
electrochemical, electrical,
mechanical, electromechanical. and thermoelectric. Applications
to biomedical systems.
Prerequisites: EBME 310.
EBME
405. Materials
for Prosthetics and Orthotics (3)
Fundamental concepts of metallic and ceramic materials.
Wear, corrosion, and failure of implants. Properties
of hard tissues and joints. Characterization of biomaterials.
Biocompatibility of materials. Orthopaedic and dental
applications.
Prerequisite: EBME
306.
EBME
406. Polymers
in Medicine (3)
Plastic implants in the body. Chemical and physical characteristics
of biomedical polymers.
Implant requirements, host-implants reactions. Physiological
and biomechanical basis for soft-tissue implants. Design
of modified biometerials.
Prerequisite: Consent of instructor.
EBME
407. Applied
Neural Control (3)
Fundamental concepts related to electrical stimulation
of the nervous system. Cable equation, currents in volume
conductors, electrical models of axons, interaction between
axons and electrical fields, tissue damage of electrical
stimulation, electrochemistry of electrical stimulation,
electrodes for electrical stimulation, applications to
neuromuscular, sensory, and other physiological systems.
Prerequisites: EBME
451.
EBME
408. Tissue
and Cell Engineering (3)
Tissue engineering approach for augmentation or replacement
of compromised tissue function in nerve, microvessels,
skin and cartilage. Integrative exploration of the use
of three-dimensional polymeric scaffolds and drug delivery
vehicles, and gene therapy and cellular engineering for
functional repair of injured tissues.
Prerequisite: Consent of instructor.
EBME
409. Systems
and Signals in Biomedical Engineering (3)
Fourier series and transforms. Sampling and noise. Digital
filtering. Dynamic systems. Initial-value problem. Laplace
transform. System linearization. Frequency response analysis.
Nonlinear systems and maps. Numerical methods. Distributed
systems. Application to biomedical problems.
Prerequisite: EECS
212 (or equivalent).
EBME
410. Medical
Imaging Fundamentals (3)
Physical principles of medical imaging. Imaging devices
for x-ray, ultrasound, magnetic resonance, etc. Image
quality descriptions. Patient risk.
Prerequisites: EBME
310, EBME 409.
EBME
412. Biomedical
Signal Processing (3)
Application of digital processing techniques to biomedical
signals. Spectra and digital filters.
Processing evoked responses. Electrocardiograms, electroencephalograms,
and other biomedical applications.
Prerequisite: EBME
409.
EBME
416. Biomedical
Signal Processing (3)
This course is designed to provide students with a basic understanding of the principles behind controlled release drug delivery. Various types of drug and gene delivery routes including transdermal, implantable, targeted and pulmonary will be discussed. The course will highlight the rational design of drug delivery devices based on the fundamental understanding in pharmacology, chemistry, biomaterials science and engineering. Integration of biomaterial structure and function will be emphasized throughout the course.
Prerequisite: EBME
306 or graduate standing.
EBME
417. Excitable
Cells: Molecular Mechanisms (3)
Ion channels are the molecular basis of membrane excitability
in all cell types, including neural, heart, and muscle
cells. This course presents the structure and the mechanism
of function of ion channels at the molecular level. It
introduces the basic principles and methods in the ion
channel study including the ionic basis of membrane excitability,
thermodynamic and kinetic analysis of channel function,
voltage clamp and patch clamp techniques, and molecular
and structural biology approaches. The course will cover
structure of various potassium, calcium, sodium, and
chloride channels and their physiological function in
neural, cardiac, and musclecells. Exemplary channels
that have been best studied willbe discussed to illustrate
the current understanding of themolecular mechanisms
of channel gating and permeation.
Prerequisites: EBME
201.
EBME
418. Electronics
for Biomedical Engineering (3)
Review of electronic circuits. Analog design for biomedical
electronics. Low noise, precision amplification, shielding,
grounding, interfacing, and electrical safety. Electrophysiological
amplifiers and biomagnetic field measurements.
Prerequisite: EBME
308 or consent of instructor.
EBME
426. Gene
and Drug Delivery (3)
The teaching objective is to provide students with a
basic understanding of the principles of design and engineering
of well-defined molecular structures and architectures
intended for applications in controlled release and organ-targeted
drug delivery. The course will discuss the therapeutic
basis of drug delivery based on drug pharmacodynamics
and clinical pharmacokinetics. Biomaterials with specialized
structural and interfacial properties will be introduced
to achieve drug targeting and controlled release.
Prerequisites: EBME
306.
EBME
427. Movement
Biomechanics and Rehabilitation (3)
Introduction to the basic biomechanics of human movement
and applications to the design and evaluation of artificial
devices intended to restore or improve movement lost
due to injury or disease. Measurement techniques in movement
biomechanics, including motion analysis, electromyography,
and gait analysis. Introduction to musculoskeletal modeling
and simulation. Survey of movement pathologies and engineered
interventions, including arthritis and joint replacements,
amputation and upper and lower limb prostheses, and spinal
cord injury and neuroprostheses.
Prerequisite: Consent of instructor,
graduate standing.
EBME
431. Physics
of Imaging (3)
Magnetic resonance imaging including Bloch equations,
relaxation times, chemical shifts.
Reconstruction techniques including 2-D Fourier transforms.
Biomedical applications.
Prerequisite: EBME
410, PHYS
122, or PHYS
124.
EBME
440. Translational
Research for BME (3)
Translation of laboratory developments to improve biomedical
and clinical research and patient care. Evaluation of
technology and research planning with clinical and engineering
perspectives. Discussing clinical situations, shadowing
clinicians, attending Grand Rounds and Morbidity-Mortality
conferences. Understanding the basics of engineering
safe prototypes/devices. ANSI and other regulatory standards.
Validation study design. Regulatory/oversight organizations.
Protocol design and informed consent for Institutional
Review Board (IRB) approval. NIH requirements for human
safety, data safety, inclusion of minorities/women/children.
Commercialization, technology transfer, disclosure of
intellectual property, patenting, FDA approval. Special
project reports to produce IRB protocol or NIH-style
proposal.
Prerequisite: Consent of instructor.
EBME
451. Physiological
Processes I (3)
Cell and molecular biology. Nerve and muscle function.
Motor systems and feedback control. Autonomic system
mechanisms. Brain and sensory systems.
Prerequisite: Consent of instructor.
EBME
452. Physiological
Processes II (3)
Heart and vascular system. Respiratory, renal, and regulatory
systems. Gastro-intestinal system and metabolism.
Prerequisite: Consent of instructor.
EBME
460. NMR Spectroscopy
and Imaging (3)
Frontier issues in understanding the practical aspects
of NMR imaging. Theoretical descriptions are accompanied
by specific examples of pulse sequences, and basic engineering
considerations in MRI system design. Emphasis is placed
on implications and trade-offs in MRI pulse sequence
design from real-world versus theoretical perspectives.
Prerequisite: EBME
431.
EBME
461. Biomed
Image Processing and Analysis (3)
Principles of image processing and analysis with applications
to biomedical images from the nano-scale to 3D whole
organ imaging. Topics include image filtering, enhancement,
restoration, registration, morphological processing and
segmentation.
Prerequisite: EBME
308.
EBME
462. Cellular
and Molecular Imaging (3)
Frontiers in biomedical imaging to solve interdisciplinary
problems of biomedical processes and disease states at
the cellular and molecular levels.
Prerequisite: EBME
410, EBME 451.
EBME
478. Computational
Neuroscience (3)
Computational properties of nervous system. Modeling
and simulation of neurobiological systems. Neuronal development,
plasticity, and learning. Neural circuits. Neuronal dynamics.
Brain systems. Neural networks.
Prerequisite: Consent of instructor.
EBME
479. Seminar
in Computational Neuroscience (3)
Research topics in computational neuroscience. Topics
vary from year to year. Course consists of group discussions
of classic and recent papers in the field and a computer
project.
Prerequisite: Consent of instructors.
EBME
504. Transport
Processes of Biomedical Systems (3)
Mass and heat transport processes. Metabolic processes.
Spatially lumped and distributed models of organs, tissues
and cells. Numerical methods for computer simulation.
Applications to cells, tissues, and organs.
Prerequisite: Consent of instructor.
EBME
507. Motor
System Neuroprosthesis (3)
Design and implementation of neuroprostheses. Transformation
of muscle action into limb movement. Musculoskeletal
modeling and simulation. Control of the musculoskeletal
system by neural stimulation.
Prerequisite:
Consent of instructor.
EBME
513. Biomedical
Optical Diagnostics (3)
Engineering design principles of optical instrumentation
for medical diagnostics. Elastic and inelastic light
scattering theory and biomedical applications. Confocal
and multiphoton microscopy. Light propagation and optical
tomographic imaging in biological tissues. Design of
minimally invasive spectroscopic diagnostics.
Prerequisite: EBME
403 or consent of instructor.
EBME
519. Parameter
Estimation for Biomedical Systems (3)
Linear and nonlinear parameter estimation of static and
dynamic models. Identifiability and parameter sensitivity
analysis. Statistical and optimization methods. Design
of optimal experiments. Applications to cells, tissues,
and organs.
Prerequisite: Consent of instructor.
EBME
523. Chemical & Optical
Sensors (3)
Fundamental electrical, electrochemical, and optical
measurement techniques. Sensitive and selective biological
membranes based on ion, enzyme, and immuno-reactions.
Sensor stability and response time.
Prerequisite: EBME
403. |
