EBME 519. Parameter Estimation for Biomedical
Systems
Course Syllabus
Textbook
None
References
Many books and articles (see web site)
Course Topics
1. Concepts basic to estimation - Ventilation-perfusion
distribution
2. Linear statistical estimation - Inverse problem:
electrocardiography
3. Nonlinear estimation: direct and gradient - Dependence
of heart rate on ACh
4. Constrained optimization - Nonlinear elastic lung
model; Regularization in electrocardiography
5. Dynamic models - CO2 control of breathing,
Electrotonic parameters of neurons
6. Identifiability and sensitivity - Iron kinetics
in blood; PET ligand-receptor model
7. Response surfaces and confidence regions - LDL transport
parameters
8. Optimal experiment design - PET quantification of
receptor density; Glucose tracer kinetics
9. Multi-objective criteria for ferrokinetics |
