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EBME 504. Transport Processes of Biomedical Systems
Course Syllabus
Textbook
None
References
Many books and articles (see web site)
Course Topics
| I. Compartmental analysis of mass
transport |
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Spatially lumped models, dimensionless forms,
numerical solution for ODEs, pulmonary transport
abnormalities, tissue-capillary transport, PET
receptor concentration, multi-organ drug distribution,
metastatic process |
| II. Spatially distributed models
of mass transport |
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One-dimensional models, plug transport & axial
dispersion models, Laplace transform applied to
PDEs, point sources and boundary conditions, continuous
and discrete models, eigenfunction expansion, Duhamel's
theorem, CT scans of micro-circulation, diffusion
and metabolism in tissues, diffusion in tissue
culture, transport in arterial wall |
| III. Distributed, multi-phase mass
transport |
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Bessel functions, alternative coordinate systems,
transport in arterial wall with injuries, pulmonary-capillary
transport, perfused tissue transport, local vascular
drug delivery, micro-electrode diffusion, oxygen
transport in skin |
| IV. Generalized spatially distributed
transport |
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Multi-dimensional balances, convective-diffusive
mass balances, factor X activation in a flow reactor,
cell size distribution dynamics,tumor vascularization
and growth, analysis of thrombolytic therapy |
| V. Energy transport |
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Energy balances, dynamic, 1-D heat conduction,
numerical method of lines, skin thermal response,
brain cooling during cardiopulmonary bypass, thermal
model for cerebral perfusion, counter-current heat
exchange, air-mucus water and heat exchange, tracheal
humidification, tumor destruction with RF heating |
| VI. Momentum transport |
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Momentum and mass balances in 3-D, Hagen-Poiseuille
flow, platelet deposition and activation, boundary
layer flow, convective diffusion: rotating disk,
platelet-mediated adhesion |
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