EBME 474. Bio-transport Processes
Description
The primary goal of this course is to develop a quantitative understanding of mass transport and
chemical reaction processes in systems of biological and medical importance. Basic mechanisms
and mathematical model development will be emphasized using conservation principles.
Analytical and numerical methods will be applied to solve algebraic and differential equations to
simulate in vivo processes as well as to develop diagnostic and therapeutic methods.
Course Outline
Basic concepts in mass transport
Equilibrium thermodynamics with biomedical examples
Reaction equilibrium with biomedical examples
Diffusion processes with biomedical examples
Biomedical membrane transport
Chemical reaction processes with biomedical examples
Multidimensional mass & momentum transport
Convective processes: flow in tubes, boundary layer flow, flow through porous media
Multidimensional species mass transport with biomedical examples
Diffusion with convection with biomedical examples
Diffusion with chemical reaction with biomedical examples
Cell population dynamics with biomedical examples
Biomedical Examples
Disk electrode as O2 biosensor, reactive gas transport in lung, encapsulated enzyme reactor,
macromolecular transport in artery wall, gas transport in airway wall, transport in perfused
tissues, artificial membrane transport, transport in cell culture, blood coagulation factor in flow
reactor, axon growth, endothelial cell migration, nutrient transport in cell culture, tumor
vascularization & growth, chemotaxis with inflammatory response, stem cells for cartilage tissue
engineering, O2 transport in extracorporeal liver, epidermal regeneration in composite skin, drug
distribution in tissues, intra-vascular drug delivery, intra-cranial drug delivery
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