EBME 408. Tissue and Cell Engineering
Course Syllabus
References
Class handouts of lectures and research papers, including critical reviews, are used as notes and reference.
Course Topics
1. Tissue development – Nature’s “Gold Standard” for Engineering Tissue – What makes tissues different?
2. Specific Tissue Types
3. Tissue development – Review of growth factors, morphogens, etc.
4. Evolution of Circulatory Networks for Transport Efficiency: from unicellular to multiorgan systems
5. Nature’s Paradigms: Patterning in Development – Interplay between biophysical and biochemical signals in development of plants and limbs (role of transport and mechanics - Pauwels, Thompson, etc.), Wit signaling pathways
6. Wound Healing: Recapitulation of Embryonic Development, review of biochemical factors including cytokines, etc., role of cells, interplay between biophysical and biochemical signals in wound healing
7. Cells: Nature’s Micromachines for Regeneration and Repair – Physiology and recruitment gene therapy, review of cell signaling molecules and pathways; how to recruit cells to the right place at the right time – or – how to influence cell differentiation – or – How to engineer a cell?
8. Stem Cells
9. Reverse Engineering of Bioactive Tissues: Case study blood vessel – vascular graft, case study bone tissue – bone graft substitutes
10. Endogeneous Strategies for Cell and Tissue Engineering: Engineering for Function, engineering for Cell Survival, engineering for “Product Safety and Lifetime”
11. Plastic and reconstructive surgery: transplantation of limbs and faces
12. Principles of Scaffold Design – Material considerations, transport considerations, bioreactors, cell seeding and metabolism considerations
13. Interface Biology – Biocompatibility/immunogenicity, surface modifications and design of molecular interfaces
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