EBME 408. Tissue and Cell Engineering
Description
Tissue engineering approach for augmentation or replacement
of compromised tissue function in nerve, microvessels,
skin and cartilage. Integrative exploration of the
use of three-dimensional polymeric scaffolds and
drug delivery vehicles, and gene therapy and cellular
engineering for functional repair of injured tissues.
Course Goals
This course aims to provide students with a foundation
based on “Nature’s design and optimization” criteria
for engineering tissues. This will be achieved through
focused review of the principles of development,
wound healing, regeneration, and repair through remodeling,
using Nature as a paradigm. Principles of transport
will be explored quantitatively and in relation to
multiorganismal evolution. Cellular engineering principles
will be explored, including quantitative approaches
to energy balance between cells and their environment
(metabolism), gene therapy and current state of the
art in stem cell physiology and therapeutic applications.
Endogeneous approaches to surgical tissue reconstruction
will be outlined and guest lecturers will describe
examples of clinical applications. An overview of
contemporary approaches to tissue and cell engineering
will be given, including tissue scaffold design,
use of bioreactors in tissue engineering, and molecular
surface modifications for integration of engineered
tissues in situ.
Throughout the course, emphasis is placed on connective
tissues including skin, fat, bone, cartilage and tendon.
Fundamental engineering principles will be augmented
through guest lectures describing specific applications.
Ethical considerations related to clinical application
of tissue and cell engineering technology will be integrated
into each lecture.
Prerequisites
College level physiology, core intro engineering course
to fluid mechanics and fluid dynamics.
Class/laboratory Schedule
Two 75 minute sessions per week. Review sessions before
each exam.
Typical Class Size
Capped at 50
Semesters and Years Offered
Offered spring every year.
Course Objectives
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