EBME 401. Bioelectric Phenomena
Course Syllabus
Textbook
Bioelectromagnetic Phenomena. Malmivuo, Plonsey
Course Topics
1. History of Bioelectromagnetism
2. Nerve and muscle cells
3. Subthreshold phenomena
a. Nernst-equation
b. Nernst-Planck equation
c. Origin of the resting potential
d. The Donnan equilibrium
e. Constant-field-membrane model
f. Membrane conductivity and rectification
g. Active Transport
h. Cable equation (Rall W: Cable Theory)
4. Active behavior of the cell
a. Voltage clamp method
b. Non-linear membrane behavior (Hodgkin Huxley article)
c. Hodgkin-Huxley model
d. Simulation of the membrane potential (Koch and Segev, Numerical
Methods in Neuroscience)
e. Propagation of the action potential
f. Simulation of the cardiac action potential
g. Patch clamp and ionic channels
h. Formulation of stochastic channel mechanisms (Johnston and
Wu: Foundation of Cellular physiology)
5. Vector Analysis (Barr and Plonsey: Bioelectricity,
a quantitative approach)
a. Gradient-divergence-Curl-Laplacian
b. Gauss Theorem-Green Theorem
6. Volume conductors
a. The human body as a volume conductor
b. Quasi-static formulation of Maxwell equations
c. Inhomogenous and Anisotropic media (Nunez: Electric fields
of the brain)
d. Conductivity measurements (Plonsey: Bioelectricity)
7. Volume sources
a. Field of single cell (Plonsey: Bioelectricity)
b. Volume-conductor potentials from equivalent sources (Plonsey:
Bioelectricity)
c. Transmembrane potential as a source function (Plonse:, Bioelectricity)
d. Secondary-source representation of volume-conductor inhomogeneities
(Plonsey, Bioelectricity)
e. Nerve Recording (Stein: Nerve and muscles)
f. Current-source analysis (Johnston and Wu: Foundation of
Cellular Physiology)
8. Electric an magnetic field interaction with the
nervous sytem
a. Membrane polarization (Ranck: Electrical Stimulation)
b. Activation Function: Myelinated and unmylinated fibers (Rattay:
Electrical Nerve Stimulation)
c. Electrical Stimulation Simulation (McNeil: IEEE Article)
d. Strength duration Curve
e. Magnetic stimulation (Basser and Roth: IEEE Article)
9. Applications and examples in the cardiac system
a. Physiology and anatomy of the heart
b. Electric measurement of the electric activity of the heart
c. Macroscopic cardiac sources
d. Abnormal activity and propagation of the heart
e. Cell-Cell communications model (Class Notes)
f. Lui-Rudy model (Lui Rudy ) |
