EBME 317. Excitable Cells: Molecular Mechanisms
Course Syllabus
Textbook
Ion Channels of Excitable Membranes. Hille
From Neuron to Brain. Nicholls, Martin, Wallace, Fuchs
Course Topics
1. Overview: Ionic basis of membrane excitability,
action potentials are generated by variety of ion
channels, ion channels viewed by different methods
that are used to study them
2. Ion permeation and selectivity: Basic principles
and theories, properties of pores, selectivity of ion
channels
3. Channel gating: Channel activation: voltage sensing,
channel activation: gating, inactivation of ion channels,
macroscopic (whole-cell) current analysis, voltage
dependent gating is modulated by hetero-subunits, ionic
currents - two-state model, single channel activity
and analysis, open channel block
4. Diverse ion channels: Gap junction channels, ligand-gated
channels: diversity and structure-function, calcium
channels, chloride channels, ion channels are associated
with other proteins in signal transduction
5. Several sessions of journal club-style presentations
by graduate students. Undergraduate students will participate
in discussion. |
