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BIOMEDICAL IMAGING LABORATORY
Bright field cryo-image of a whole mouse. Cryo-imaging enables high resolution 3-D color imaging in bright field and fluorescence with the acquisition of several slices, such as the one pictured above, at 10-40 micrometer intervals.
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The Biomedical Imaging Laboratory, headed by Professor David L. Wilson, conducts medically relevant research in imaging science and offers training to students. The laboratory has projects funded by research grants from NIH and the Whitaker Foundation.
The laboratory has several graduate students conducting ground-breaking research in the field of image processing. State-of-the-art computing facilities are available, including a number of workstations with programs such as Amira, Matlab, and Analyze, as well as several custom applications developed within the lab. The lab works closely with the Case Center for Imaging Research, which houses state of the art imaging facilities for both human and small animal MRI, CT, PET, SPECT, and small animal bioluminescence and cryo-imaging.
Cryo-imaging is a novel method developed in Dr. Wilson's laboratory that serially sections and images the block face of a frozen specimen, providing ultra-high-resolution RGB and fluorescence volumes. It consists of a mouse-sized cryomicrotome; microscope; low light camera; three-axis robotic positioning system; and automation, visualization, and analysis software. The development of new technology in conjunction with further advances in established imaging applications puts the Biomedical Imaging Laboratory on the forefront of imaging science.
An MRI image of a patient’s neck corrected for intensity inhomogeneity. The arrow shows a plaque in the left carotid artery.
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The lab focus areas currently include:
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Development of a novel cryo-imaging system |
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Development of advanced quantitative MR imaging techniques, such as for obesity research |
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Computer-Aided Diagnosis in MRI, such as for artherosclerosis |
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Quantitative Image Quality in X-Ray Fluoroscopy and MRI |
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Advanced Image Segmentation algorithms |
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Three-Dimensional Image Registration |
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Bioluminescent Cellular and Molecular Imaging |
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The Biomedical Imaging Lab is currently located on the fourth floor of the Wickenden Building at Case Western Reserve University,
where it moved into a newly renovated laboratory space in summer 2005.
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