Building Better Materials for Better Therapies
Biomaterials can be defined as any materials, natural or synthetic, which are used therapeutically to repair, restore or replace lost function. While such materials have been around for decades, continuous improvements in the understanding of how the body interacts with implanted materials led to the progression of this field from the use of anything which was surgically available to use of materials which were deemed biocompatible.
Recent advances have been in exploring materials which are not passive and walled off by the body but actively participate in the body's efforts to repair itself. Such biomimetic and bioactive materials are designed to more accurately mimic the body's natural structures and functions from macro to micro to nano levels.
Specific research in the Department of Biomedical Engineering at Case Western Reserve University focuses on the development of new materials and material coatings and the use of materials in the delivery of therapeutic products (drug delivery). Additionally, research in tissue engineering focuses on combining materials with cellular technologies to create hybrids, which are able to grow and repair themselves.
Biomaterials applications include cardiovascular biomimetic materials and analysis of biocompatibility and hemocompatibility. Other research involves polymeric surface coatings for implants and sensors, as well as hostbiomaterial interactions. Another application area is cutting-edge research in nano-scale orthopedic biomaterials and hard/soft tissue biomechanics.
Tissue engineering research at Case Western Reserve ranges from multi-scale modeling of transport within engineered tissues, to development of novel degradable materials, to use of adult and embryonic stem cells as research tools. Applications include orthopedic, cardiovascular, and neural tissues.
Researchers in drug delivery are exploring new paradigms in how drugs are released from devices, combining delivery with in vivo imaging, and creating micro and nano drug carriers. Applications include cardiovascular therapy, cancer therapy, HIV, surgical site infections, and orthopedic and ophthalmological applications.
Biomaterials & Tissue Engineering Faculty
|Primary Faculty||Research Interests||Email Address|
|Biomimetic tissue engineering; innovative biomaterials and drug delivery vehicles for functional tissue regeneration; control of stem cell fate decision; precise temporal and spatial signal presentation to regulate cell behavior; influence of mechanics on cell behavior and tissue formation; cell-cell email@example.com|
|Synthesis and measurement of orthopedica tissues and biomaterials with an emphasis on nanoscale measurement and design firstname.lastname@example.org|
|KNOTHE TATE,Melissa||Development of preventative, treatment and replacement measures for bone disease and failure; Multi-scale modeling of the interplay between mechanics and transport in biological systems: cell mechanics => tissue email@example.com|
|Biomaterials, synthesis of new degradable polymers; tissue engineering; spinal cord repair; retinal regeneration; drug delivery for optic nerve preservation and firstname.lastname@example.org|
|Surface modification of cardiovascular devices; molecular level structure and function of plasma proteins; liposome drug delivery systems; mechanisms of bacterial adhesion to email@example.com|
|Development and surface-modification of lipidic and polymeric nanoparticles for "targeting" cardiovascular and cancer pathology, thereby providing a platform for "targeted nanomedicine and molecular imaging"; development and characterization of novel amino-acid based polymeric systems for potential application in tissue engineering firstname.lastname@example.org|
|Novel polymer platforms for gene and drug delivery; directed stem cell differentiation for engineering tissues from non-proliferative email@example.com|
|Associated Faculty||Research Interests||Email Address|
|Blood and tissue/material interactions; implantable devices and biomaterials; firstname.lastname@example.org|
|Microvascular tissue engineering, cell migration in wound healing, inflammation, and cancer email@example.com|
|Neural penetrating electrodes; biomaterial surface science; biomimetic materials; and polymer firstname.lastname@example.org|
|Use of adult Mesenchymal Stem Cells for tissue engineered regeneration of skeletal tissues and for cell-based therapies for asthma, multiple sclerosis, infarct, and graft-versus-host email@example.com|
|Computer-assisted surgery; skull (bone) tissue engineering; photodynamic therapy of glioma; automated radiosurgery treatment firstname.lastname@example.org|
|Tissue engineering of cartilage subtypes; total joint resurfacing; engineering of neo-trachea; targeted stem-cell email@example.com|
|Tendon mechanobiology and tissue firstname.lastname@example.org|
|Innovative applications of biocompatible polymers and other biomaterials in imaging and interventional email@example.com|
|Healing of prosthetic vascular grafts||grahamL@ccf.org|
|Bone mechanics; bone adaptation; multi-scale mechanics; firstname.lastname@example.org|
|Cellular function and gene expression on biomimetic surfaces and tissue engineering scaffolds; interaction of blood and email@example.com|
|Mineralization of vertebrates; effect of mechanical force on mineralization; calcium transport in mineralization; tissue firstname.lastname@example.org|
|Bone tissue engineering; osteoblastic differentiation; age, gender, and diseaserelated changes in connective tissue email@example.com|
|Optimization of cardiac function following myocardial infarction with an emphasis on developing novel strategies for cell and gene based tissue firstname.lastname@example.org|
|Mechanical behavior and constitutive modeling of materials in total joint replacements; damage/fracture behavior of bone tissue||Clare.Rimnac@case.edu|
|Investigation and utlization of Supramolecular Chemistry (chemistry of non-covalent bond) in polymer chemistry||Stuart.Rowan@case.edu|
|Continuous magnetic cell sorting; cell tracking velocimetry; magnetic nanoparticle email@example.com|
|Self-assembling, non-viral gene-therapy; proteomics in cystic fibrosis; redox mediated inflammatory signaling in the firstname.lastname@example.org|
|Vascular grafts; cell-material interactions; extra cellular matrix; tissue engineering; blood email@example.com|
Affiliated Labs and Centers