Research in biomedical systems, sensors, and simulation involves acquiring biological information at multiple scales with state-of-the-art methodologies, multi-scale integration of mechanisms and phenomena with computational models, and simulation and analysis of acute and chronic physiological system behavior.

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Biomedical Sensors

Biomedical sensing integrates biologically derived sensing components with a transducer for in vitro and in vivo measurements of chemical and biological substances. Research includes the development and use of electrochemical, optical mini- and micro-sensors, micro-fabricated devices such as BioMEMS chips, quantitative analysis of cellular transport and communication, cost-effective in vitro diagnostics, and continuous in vivo diagnostics.

Metabolic Systems

Mathematical modeling and computer simulation are used to analyze changes in cellular metabolism of tissues, organs, and the whole body. Non-invasive or minimally invasive measurements are obtained with human exercise studies under normal and diseased conditions. Cellular metabolic changes are quantitatively related to physiological changes. Projects include cellular metabolic mechanisms of myocardial ischemia, cellular metabolism and energetics in skeletal muscle, adipose tissue metabolism with insulin resistance, and whole-body energy balance.

Cardiac and Vascular Systems

Cellular and molecular imaging technologies and mathematical modeling are combined with molecular, cellular, and tissue measurements to analyze mechanisms of heart disease. Therapeutic strategies are developed related to biomechanical, vascular, and electrophysiological functions. Cardiovascular physiology and metabolic regulation are studied using ECG signals, magnetic resonance imaging, optical mapping, and spectroscopy. Projects include cellular mechanisms of sudden cardiac death, cell and gene therapy for arrhythmias, ion channel structure and function, and myocardial ischemia.

Musculoskeletal Mechanics

Engineering mechanics is applied to study the structure and function of musculoskeletal systems. This research leads to the design of clinical interventions including artificial joints, prosthetic limbs, dental implants, bone healing, and methods to counteract loss of bone and muscle during space travel. Projects include computational musculoskeletal modeling, bone biomechanics, muscular control systems, human locomotion, and exercise to reduce loss of musculoskeletal function in space.

Affiliated Labs and Centers

Laboratory for Biomedical Sensing

Experimental and Computational Mechanobiology Laboratories

Cardiovascular Research and Imaging Center

The Heart and Vascular Research Center (HVRC), MetroHealth Medical Center

Modeling and Analysis of Physiological Systems

Faculty

Faculty	Research Interests	Email Address
Biomedical Sensors
GRATZL, Miklos	Biochemical sensing and diagnostics in vitro and in vivo; electrochemical and optical micro-techniques; MEMS for assessing cellular transport; cancer pharmacology at the single cell level; sliver sensor for multianalyte patient monitoring	mxg13@case.edu
Metabolic Systems
SAIDEL, Gerald	Mass & heat transport and metabolic analysis in cells, tissues, & organs; mathematical modeling, simulation, parameter estimation; optimal experimental design; metabolic dynamics; minimally invasive thermal tumor ablation; slow release drug delivery	gms3@case.edu
LAI, Nicola	Modeling and control of metabolic processes; metabolic regulation in hypoxia, ischaemia and exercise	nicola.lai@case.edu
Cardiac and Vascular Systems
CHENG, Yuanna	Cardiac imaging, mechanisms of arrhythmias, implantable defibrillators, cardiac remodeling, antiarrhythmic therapy	chengy@ccf.org
DESCHENES, Isabelle >>	Molecular imaging, ion channel structure and function, genetic regulation of ion channels, cellular and molecular mechanisms of cardiac arrhythmias	ideschenes@metrohealth.org
DONAHUE, J. Kevin >>	Mechanisms for cardiac arrhythmias; cardiac electrophysicology; in vivo cardiac mapping; gene delivery systems and methods; gene therapy	kdonahue@metrohealth.org
LAURITA, Kenneth >>	Novel biological therapies for sudden cardiac death; cellular mechanisms of cardiac arrhythmias using fluorescent imaging of transmembrane potential and intracellular calcium; instrumentation and software design for real-time cardiac mapping	krl2@case.edu
ROSENBAUM, David S.	Cellular mechanisms of cardiac arrhythmias, fluorescent imaging of transmembrane potential and intracellular calcium; cardiac repolarization; impulse propagation and block; instrumentation and software for imaging electrical activity	drosenbaum@metrohealth.org
WALDO, Albert L.	Cardiac electrophysiology and cardiac excitation mapping	alw2@case.edu
PENN, Mark	Myocardial ischemia, vascular biology, cardiac critical care	pennm@ccf.org
THOMAS, James	Echocardiography
YU, Xin	MRI and MRS for characterization of cardiac disease	xin.yu@case.edu
Musculoskeletal Mechanics
KNOTHE TATE, Melissa	Harnessing nature's development and healing capacities; applying nature's paradigm to develop novel mechnoactive materials; mechanically modulated transport in tissues and biomaterials	knothetate@case.edu
van den BOGERT, Antonie	Computational musculoskeletal modeling and experimental analysis of human posture and locomotion	bogerta@ccf.org