Stimulating the Future of Medicine

Neural engineering and rehabilitation research applies neuroscience and engineering methods to analyze central and peripheral nervous system function and to design clinical solutions to neurological disorders or injury. Through the application of basic science and engineering techniques, neural engineers develop methods to record from and exert control over the nervous system and associated organ systems. Primary faculty, associated faculty, research associates, and students work in three national centers of education and research in neural engineering and rehabilitation. Our research teams collaborate with four local major medical facilities: MetroHealth Medical Center, University Hospitals Case Medical Center, Cleveland Clinic, and The Louis Stokes Cleveland VA Medical Center. Neural engineering facilities allow researchers to take ideas from basic science through experimental testing and to clinical deployment. Neural engineering research teams are funded by commercial partnerships and grants, including those from the State of Ohio, National Institutes of Health, and other federal sources - in excess of $26 million. Below are a few examples of the ongoing research and applications in neural engineering and rehabilitation.

Neural prostheses, neural rehabilitation engineering, and neuromodulation: Technologies for treating and managing consequences of stroke, spinal cord injury, epilepsy, genito-urinary function, pain, and multiple sclerosis; robot-assisted rehabilitation; deep brain stimulation for treating movement disorders

Neurophysiology: Synchronization and control of neural activity in-vivo and in-vitro, spinal neural circuits, and stochastic resonance in neural networks

Advanced prosthetics and orthotics: Implanted devices to directly communicate with the residual nervous system for control and sensory feedback in amputee prosthetics

Neural and biomechanical computation: Computational neuroscience; simulation of nerve electrodes, musculo-skeletal systems, and biomechanics; advanced control algorithms

Neural and brain machine interfaces: Bio-inspired materials, cellular-level neural connection, EEG and microelectrodes for cortical control of assistive technologies

Neural imaging and sensing: Voltage sensitive dyes, microelectrode arrays, and fluorescent immunohistochemistry of neural tissue responses

Neural Engineering & Rehabilitation Faculty

Primary Faculty	Research Interests	Email Address
CRAGO, Patrick E.	Control of neuroprostheses for motor function; neuromuscular control systems	pec3@case.edu
DURAND, Dominique M.	Neural engineering; neuroprostheses; neural dynamics; electric and magnetic stimulation of the nervous system; neural interfaces with electronic devices; analysis and control of epilepsy	dxd6@case.edu
GUSTAFSON, Kenneth	Neural engineering; neural prostheses; neurophysiology and neural control of genitourinary function; devices to restore genitourinary function; functional neuromuscular stimulation	kjg@case.edu
KIRSCH, Robert	Functional neuromuscular stimulation; biomechanics and neural control of human movement; modeling and simulation of musculoskeletal systems; identification of physiological systems	rfk3@case.edu
Lavik, Erin	Biomaterials, synthesis of new degradable polymers; tissue engineering; spinal cord repair; retinal regeneration; drug delivery for optic nerve preservation and repair	erin.lavik@case.edu
PECKHAM, P. Hunter	Neural prostheses, implantable stimulation and control; control of movement; rehabilitation engineering	pxp2@case.edu
TAYLOR, Dawn	Brain-computer interfaces for control of computers, neural prostheses, and robotic devices; Invasive and non-invasive brain signal acquisition; Adaptive decoding algorithms for retraining the brain to control alternative devices after paralysis.	dxt42@case.edu
TYLER, Dustin	Neuromimetic neuroprostheses; laryngeal neuroprostheses; clinical implementation of nerve electrodes; cortical neuroprostheses; minimally invasive implantation techniques; modeling of neural stimulation and neuroprostheses.	dxt23@case.edu
Research Faculty	Research Interests	Email Address
BHADRA, Niloy	Experimental and computational studies of high frequency waveforms for reversible conduction block of peripheral nerves; design, testing and implementation of neuroprosthetic systems for the upper limb	niloy.bhadra@case.edu
Associated Faculty	Research Interests	Email Address
BURGESS, Richard C.	EEG, MEG, epilepsy, sleep disorders, computer processing of electrophysiologic signals, continuous computerized neurophysiologic assessment, telemedicine	burgesr@ccf.org
CAPADONA, Jeffrey	Engineering the electrode and tissue interface	jcapadona@aptcenter.org
CHAE, John	Application of neuroprotheses in hemiplegia	jchae@metrohealth.org
CHIEL, Hillel J.	Biomechanical and neural basis of feeding behavior in the marine mollusk Aplysia californica; neuromechanical system modeling; analysis of neural network dynamics	hjc@case.edu
DEAN, David	Computer-assisted surgery; skull (bone) tissue engineering; photodynamic therapy of glioma; automated radiosurgery treatment planning	david.dean@case.edu
DELL'OSSO, Louis F.	Neurophysiological and ocular motor control systems	lfd@case.edu
KILGORE, Kevin	Functional electrical stimulation; hand protheses	kkilgore@methrohealth.org
LEIGH, R. John	Normal and abnormal motor control of the eye	rjl4@case.edu
MCINTYRE, Cameron	Theoretical modeling of the interaction between electric fields and the nervous system; deep brain stimulation	mcintyd@ccf.org
REZAI, Ali R.	Deep brain stimulation	rezaia@ccf.org
TRIOLO, Ronald	Biomechanics and control of posture, balance, and walking; neuroprostheses and lower limb prosthetics; neurorehabilitation and assistive technology	rxt24@case.edu
YUE, Guang H.	Neural control of movement	yueg@ccf.org

Affiliated Labs and Centers

•	Advanced Platform Technology Center
•	Autonomic Neural Prostheses and Neurophysiology Laboratory
•	Functional Electrical Stimulation Laboratory
•	Neural Engineering Center
•	Neurological Surgery Imaging Laboratory
•	Laboratory for Neuromimetic & Neural Integrated Systems
•	Darnoff-Dell'Osso Ocular Mobility Laboratory
•	Kirsch Functional Restoration Group