Graduate students with various undergraduate backgrounds will learn the fundamental principles of biomedical measurements that integrate instrumentation and signal processing with problem-based hands-on experience

Together with EBME 402 and CBIO 453 this forms the Graduate Core Curriculum for PhD studies in Biomedical Engineering.

Requirements:  Graduate Standing

Graduate students with various undergraduate backgrounds will learn the fundamental principles of organ and tissue physiology as well as systems modeling

Together with EBME 401 and CBIO 453 this forms the Graduate Core Curriculum for PhD studies in Biomedical Engineering.

Requirements:  Graduate Standing

Plastic implants in the body. Chemical and physical characteristics of biomedical polymers. Implant requirements, host-implants reactions. Physiological and biomechanical basis for soft-tissue implants. Design of modified biometerials. .

Fundamental concepts related to electrical stimulation of the nervous system. Cable equation, currents in volume conductors, electrical models of axons, interaction between axons and electrical fields, tissue damage of electrical stimulation, electrochemistry of electrical stimulation, electrodes for electrical stimulation, applications to neuromuscular, sensory, and other physiological systems.

Physical principles of medical imaging. Imaging devices forx-ray, ultrasound, magnetic resonance, etc. Image quality descriptions. Patient risk.

This course is designed to provide students with a basic understanding of the principles behind controlled release drug delivery. Various types of drug and gene delivery routes including transdermal, implantable, targeted and pulmonary will be discussed. The course will highlight the rational design of drug delivery devices based on the fundamental understanding in pharmacology, chemistry, biomaterials science and engineering. Integration of biomaterial structure and function will be emphasized throughout the course.

Prerequisites

Graduate standing, and one year of introductory biomaterials class (e.g. EBME 306). Required:  PHRM 309/409.

Ion channels are the molecular basis of membrane excitability in all cell types, including neural, heart, and muscle cells. This course presents the structure and the mechanism of function of ion channels at the molecular level. It introduces the basic principles and methods in the ion channel study including the ionic basis of membrane excitability, thermodynamic and kinetic analysis of channel function, voltage clamp and patch clamp techniques, and molecular and structural biology approaches. The course will cover structure of various potassium, calcium, sodium, and chloride channels and their physiological function in neural, cardiac, and musclecells. Exemplary channels that have been best studied willbe discussed to illustrate the current understanding of themolecular mechanisms of channel gating and permeation.

Review of electronic circuits. Analog design for biomedical electronics. Low noise, precision amplification, shielding, grounding, interfacing, and electrical safety. Electrophysiological amplifiers and biomagnetic field measurements.

Models of excitable cells and membranes. Neural and Cardiac action potentials. Propagation of excitation. Bioelectric sources, volume conductor fields. Electric Field interaction with excitable tissue.

Models of excitable cells and membranes. Neural and Cardiac action potentials. Propagation of excitation. Bioelectric sources, volume conductor fields. Electric Field interaction with excitable tissue.

The teaching objective is to provide students with a basic understanding of the principles of design and engineering of well-defined molecular structures and architectures intended for applications in controlled release and organ-targeted drug delivery. The course will discuss the therapeutic basis of drug delivery based on drug pharmacodynamics and clinical pharmacokinetics. Biomaterials with specialized structural and interfacial properties will be introduced to achieve drug targeting and controlled release.

Introduction to the basic biomechanics of human movement and applications to the design and evaluation of artificial devices intended to restore or improve movement lost due to injury or disease. Measurement techniques in movement biomechanics, including motion analysis, electromyography, and gait analysis. Introduction to musculoskeletal modeling and simulation. Survey of movement pathologies and engineered interventions, including arthritis and joint replacements, amputation and upper and lower limb prostheses, and spinal cord injury and neuroprostheses.

Magnetic resonance imaging including Bloch equations, relaxation times, chemical shifts. Reconstruction techniques including 2-D Fourier transforms. Biomedical applications.

Translation of laboratory developments to improve biomedical and clinical research and patient care. Evaluation of technology and research planning with clinical and engineering perspectives. Discussing clinical situations, shadowing clinicians, attending Grand Rounds and Morbidity-Mortality conferences. Understanding the basics of engineering safe prototypes/devices. ANSI and other regulatory standards. Validation study design. Regulatory/oversight organizations. Protocol design and informed consent for Institutional Review Board (IRB) approval. NIH requirements for human safety, data safety, inclusion of minorities/women/children. Commercialization, technology transfer, disclosure of intellectual property, patenting, FDA approval. Special project reports to produce IRB protocol or NIH-style proposal.

Cell and molecular physiology. Basic biology of the cell, cellular transport, neuron and muscle action potential, immunity/inflammation, metabolism.

This course does not count as a technical elective in any of the undergraduate sequences!

Frontier issues in understanding the practical aspects of NMR imaging. Theoretical descriptions are accompanied by specific examples of pulse sequences, and basic engineering considerations in MRI system design. Emphasis is placed on implications and trade-offs in MRI pulse sequence design from real-world versus theoretical perspectives.

Principles of image processing and analysis with applications to biomedical images from the nano-scale to 3D whole organ imaging. Topics include image filtering, enhancement, restoration, registration, morphological processing and segmentation.

Frontiers in biomedical imaging to solve interdisciplinary problems of biomedical processes and disease states at the cellular and molecular levels.

Computational properties of nervous system. Modeling and simulation of neurobiological systems. Neuronal development, plasticity, and learning. Neural circuits. Neuronal dynamics. Brain systems. Neural networks.

Research topics in computational neuroscience. Topics vary from year to year. Course consists of group discussions of classic and recent papers in the field and a computer project.

Mass and heat transport processes. Metabolic processes. Spatially lumped and distributed models of organs, tissues and cells. Numerical methods for computer simulation. Applications to cells, tissues, and organs.

Design and implementation of neuroprostheses. Transformation of muscle action into limb movement. Musculoskeletal modeling and simulation. Control of the musculoskeletal system by neural stimulation.

Engineering design principles of optical instrumentation for medical diagnostics. Elastic and inelastic light scattering theory and biomedical applications. Confocal and multiphoton microscopy. Light propagation and optical tomographic imaging in biological tissues. Design of minimally invasive spectroscopic diagnostics.

Linear and nonlinear parameter estimation of static and dynamic models. Identifiability and parameter sensitivity analysis. Statistical and optimization methods. Design of optimal experiments. Applications to cells, tissues, and organs.

Fundamental electrical, electrochemical, and optical measurement techniques. Sensitive and selective biological membranes based on ion, enzyme, and immuno-reactions. Sensor stability and response time.

Students will be trained in topics including public speaking, grant writing, notebook management, professionalism, etc.

Requirements:  Graduate Standing.

Lectures by invited speakers on subjects of current interest in biomedical engineering.  Students will be evaluated on reading and preparation of questions for select speakers, as well as weekly participation.  Between this course and EBME 612 students must earn a minimum of 1 credit (two semesters) and can take up to 4 credits over eight different semesters.

Required for first year graduate students

Requirements:  Graduate Standing

Seminars are 4:00-5:00pm in Wickenden 322

Lectures by invited speakers on subjects of current interest in biomedical engineering.  Students will be evaluated on reading and preparation of questions for select speakers, as well as weekly participation.  Between this course and EBME 611 students must earn a minimum of 1 credit (two semesters) and can take up to 4 credits over eight different semesters.

Required for first year graduate students

Requirements:  Graduate Standing

Seminars are from 4:00-5:00pm in Wickenden 322

Lectures by students in the seminar series on subjects of current interest to biomedical engineering students in NeuroEngineering.  Students will be evaluated on presentation preparation and performance, as well as weekly participation.  Between this course and EBME 614 students must earn a minimum of 1 credit (two semesters) and can take up to 4 credits over eight different semesters.

Requirements:  Graduate Standing

Seminar:  9:00am Wickenden 105

Lectures by students in the seminar series on subjects of current interest to biomedical engineering students in NeuroEngineering.  Students will be evaluated on presentation preparation and performance, as well as weekly participation.  Between this course and EBME 614 students must earn a minimum of 1 credit (two semesters) and can take up to 4 credits over eight different semesters.

Requirements:  Graduate Standing

Seminar:  9:00am Wickenden 105

Lectures by students in the seminar series on subjects of current interest to biomedical engineering students in Imaging.  Students will be evaluated on presentation preparation and performance, as well as weekly participation.  Between this course and EBME 616 students must earn a minimum of 1 credit (two semesters) and can take up to 4 credits over eight different semesters.

Requirements:  Graduate Standing

Lectures by students in the seminar series on subjects of current interest to biomedical engineering students in Imaging.  Students will be evaluated on presentation preparation and performance, as well as weekly participation.  Between this course and EBME 616 students must earn a minimum of 1 credit (two semesters) and can take up to 4 credits over eight different semesters.

Requirements:  Graduate Standing

Lectures by students in the seminar series on subjects of current interest to biomedical engineering students in Biomaterials.  Students will be evaluated on presentation preparation and performance, as well as weekly participation.  Between this course and EBME 618 students must earn a minimum of 1 credit (two semesters) and can take up to 4 credits over eight different semesters.

Requirements:  Graduate Standing

Seminar is at 10:00 Friday mornings in Wickenden 307

Lectures by students in the seminar series on subjects of current interest to biomedical engineering students in Biomaterials.  Students will be evaluated on presentation preparation and performance, as well as weekly participation.  Between this course and EBME 618 students must earn a minimum of 1 credit (two semesters) and can take up to 4 credits over eight different semesters.

Requirements:  Graduate Standing

Seminar is at 10:00 Friday mornings in Wickenden 307