|Horst von Recum, Ph.D.
The research in our laboratory focuses on novel platforms for the delivery of molecules and cells. In the molecular delivery projects we are examining novel affinity-based systems for delivery of therapeutic agents for HIV therapies, wound dressings, ocular disease, localized chemotherapy and other applications. Affinity-based delivery uses molecular interactions to control the rate of release beyond that capable by other means such as diffusion and degradation. This allows for control of delivery to better match the physiological need of the drug.
The cellular delivery projects are examining using directed differentiation to produce tissue engineered constructs from stem cell sources. Stem cells show great promise as a therapeutic tool due to their unlimited replication potential and their plasticity, or capacity to become many different cell types. Better control of differentiation and selection, will allow for rapid expansion of high purity differentiated cells suitable for tissue engineering, toxicology and pharmacology, as well as cellular modeling, without the need for isolating cells from primary sources.
N.X. Wang, H.A. von Recum, “Affinity-Based Drug Delivery”, Macromolecular Bioscience. In Press
K.C. Harth, M.J. Rosen, *T.R. Thatiparti, M.R. Jacobs, I. Halaweish, S. Bajaksouzian, J. Furlan, H.A. von Recum, “Antibiotic-Releasing Mesh Coating To Reduce Prosthetic Sepsis: An In Vivo Study”, J Surgical Research (2010) Apr 163(2): 337-43 PMID: 20538302
*E.L. Lee, H.A. von Recum, “Cell Culture Platform with Mechanical Conditioning and Non-damaging Cellular Detachment”, J Biomed Mater Res A. (2010) May;93(2):411-8 PMID: 20358641
*T.R. Thatiparti, *A.J. Shoffstall, “Cyclodextrin-based device coatings for affinity-based release of antibiotics”, H.A. von Recum, Biomaterials (2010) Mar;31(8):2335-47 PMID: 20022369
*S.J. Kim, H.A. von Recum, “Endothelial Progenitor Populations in Differentiating Embryonic Stem Cells II: Drug Selection and Functional Characterization”, Tissue Eng Part A. (2010) Mar;16(3):1065-74 PMID: 19845466
*S.J. Kim, H.A. von Recum, “Endothelial Stem Cells and Precursors for Tissue Engineering: cell source, differentiation, selection, and application”, Tissue Eng Part B Rev. (2008) 14(1):133-47 PMID: 18454639
*T.J. Sill, H.A. von Recum, “Electrospinning for Tissue Engineering and Drug Delivery”, Biomaterials (2008) 29(13):1989-2006 PMID: 18281090
* Research Advisees