Primary Faculty

Xin Yu, Sc.D.


Xin Yu, Sc.D.
Professor

Office: Room 427 Wickenden Building
Phone: (216)-368-3918
Fax: (216)-368-4969
Email: xin.yu@case.edu
Mail Address: Room 309 Wickenden Building 2071 Martin Luther King Jr. Drive Cleveland, OH 44106-7207

Education

  • BS in Electrical Engineering, University of Science and Technology of China, 1986
  • MS in Electrical Engineering, The Johns Hopkins University, 1990
  • ScD in Radiological Sciences, Harvard-MIT Division of Health Sciences and Technology, 1996

Research Summary

My laboratory is devoted to the development of magnetic resonance imaging (MRI) and spectroscopy (MRS) methods for integrative understanding of cardiovascular physiology and diseases. We aim to apply these techniques to elucidate the structure-function and energy-function relationships in diseased hearts. We are interested in both basic science and translational clinical research that combines the state-of-the-art NMR technology with molecular biology approaches to explore the mechanisms of myocardial remodeling in diseased hearts. Currently, we are investigating the myocardial remodeling processes in genetically manipulated mouse models, muscular dystrophy and diabetes in particular.

Selected links:

• Cardiovascular Research and Imaging Laboratory
• Department of Biomedical Engineering
• Curriculum Vitae
• PubMed Citations >>
• Case Center for Imaging Research >>

Recent Publications

S Azam, CL Desjardins, M Schluchter, A Liner, JE Stelzer, X Yu, BD Hoit. Comparison of Velocity Vector Imaging Echocardiography with Magnetic Resonance Imaging in Mouse Models of Cardiomyopathy. Circ Cardiovasc Imaging. [Epub ahead of print], 2012.
   
JM Berthiaume, ME Young, X Chen, TA McElfresh, X Yu, MP Chandler. Normalizing the metabolic phenotype after myocardial infarction: impact of subchronic high fat feeding. J Mol Cell Cardiol. 53:125-33, 2012.
   
Y Chen, K Payne, VS Perara, S Huang, A Baba, T Matsuda, X Yu. Inhibition of the sodium-calcium exchanger via SEA0400 altered manganese-induced T(1) changes in isolated perfused rat hearts. NMR Biomed. [Epub ahead of print], 2012
   
W Li, M Griswold, X Yu. Fast cardiac T(1) mapping in mice using a model-based compressed sensing method. Magn Reson Med. 68:1127-1134, 2012.
   
M Lu, B Atthe, GD Mateescu, CA Flask, X Yu. Assessing mitochondrial respiration in isolated hearts using (17)O MRS. NMR Biomed. 25:883-889, 2012.
   
•  CL Ddesjardins, Y Chen, AT Coulton, BD Hoit, X Yu, JE Stelzer. Cardiac myosin binding protein C insufficiency leads to early onset of mechanical dysfunction.Circ Cardiovasc Imaging. 5:127-36, 2012.
 
•  M Lu, S Banerjee, GM Saidel, X Yu. Regulation of cytosolic and mitochondrial oxidation via malate-aspartate shuttle: an observation using dynamic ¹³C NMR spectroscopy. Adv Exp Med Biol. 701:185-192. 2011.
 
•  W Li, F Bian, P Chaudhuri, X Mao, H Brunengraber, X Yu. Delineation of substrate selection and anaplerosis in tricarboxylic acid cycle of the heart by 13C NMR spectroscopy and mass spectrometry. NMR Biomed. 24:176-187, 2011.

 

 


 



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