Anirban Sen Gupta, Ph.D. Assistant Professor Office: 519 Wickenden Building Phone: (216)368-4564 Fax: (216)368-4969 Email: anirban.sengupta@case.edu Mail Address: Room 309 Wickenden Building 2071 Martin Luther King Jr. Drive Cleveland, OH 44106-7207

Selected links:

• Sen Gupta Lab Website: iNET

Research Summary

The rapidly emerging area of nanomedicine focuses on highly specific therapeutic and diagnostic intervention within a pathologic tissue at the nanometer scale using unique nanoparticle "carrier" systems. To ensure delivery of the nanoparticles to specific pathologic tissue systems, circumvention of vascular, interstitial and cellular resistance barriers is necessary. "Targeting" provides a way to overcome such barriers and involves modification of the nanoparticle surface with specific biomolecules that can facilitate molecular recognition and binding of the particles to the pathologic cells via biologically germane ligand-receptor relationships. Nanoparticles "targeted" in this fashion can carry optimum loads of therapeutic and diagnostic agents selectively to the pathologic cells. Our laboratory focuses on the development and surface-modification of lipidic and polymeric nanoparticles for "targeting" cardiovascular and cancer pathology, thereby providing a platform for "targeted nanomedicine and molecular imaging".

The field of "tissue engineering" requires analysis of complex interactions between a biocompatible scaffold, relevant cells and, signaling molecules that promote and maintain cell recruitment, mitogenesis, differentiation and renewal within the scaffold. Often the cell-material interaction is influenced by scaffold material chemistry and scaffold morphology. Our laboratory is involved in the development and characterization of novel amino-acid based polymeric systems for potential application in tissue engineering scaffolds.

Recent Publications

•	Sen Gupta A, Wang S, Link E, Anderson EH, Hoffman C, Lewandowski J, Kottke-Marchant K, Marchant RE, Glycocalyx-mimetic Dextran-modified Poly(vinyl amine) Surfactant Coating Reduces Platelet Adhesion on Medical Grade Polycarbonate Surface, Biomaterials, in press.
•	Sen Gupta A, Huang G, Lestini BJ, Sagnella S, Kottke-Marchant K and Marchant RE, RGD-modified liposomes targeted to activated platelets as a potential vascular drug delivery system, Thrombosis and Haemostasis, 93, p. 106, 2005. (journal cover)
•	Sen Gupta A, Lopina ST, Properties of L-tyrosine based polyphosphates pertinent to potential biomaterial applications, Polymer, 46 (17), p. 2133, 2005.
•	Sen Gupta A, Lopina ST, Synthesis and characterization of L-tyrosine based novel polyphosphates, Polymer, 45 (14), p. 4653, 2004.
•	Sen Gupta A, Lopina ST, Investigation of "solid phase" synthesis of Tyrosine-derived diphenol monomers with resin-bound carbodiimide coupling reagents, J. Polym., Sci. , Part A., Polym. Chem., 42, p. 4906, 2004.