Primary Faculty

Jeffrey R. Capadona, Ph.D.

Jeffrey R. Capadona, Ph.D.
Assistant Professor

Office: Room 110 Wickenden Building
Phone: (216) 368-5486
Fax: (216) 368-1509
Mail Address: Room 309 Wickenden Building 2071 Martin Luther King Jr. Drive Cleveland, OH 44106-7207


Dr. Capadona was born in 1978 in the southwest suburbs of Chicago, IL.  He attended Saint Joseph’s College in Rensselaer, IN on an academic and athletic (baseball) scholarship.  In May 2000, Dr. Capadona received his B.S. in Chemistry, and move to Atlanta, GA to attend Georgia Institute of Technology.  In 2005, Dr. Capadona completed his Ph.D. thesis studying the effects of surface properties of biomedical implants on the control of cellular response and function.  In June of 2005, Dr. Capadona began his career with the Department of Veterans Affairs as a Research Health Scientist.  At this point, Dr. Capadona became interested in the neurodegenerative response to implanted biomedical devices.  Since joining the VA, Dr. Capadona has received an Associate Investigator Award, a Career Development Award II, and is currently the PI of two Rehabilitation R&D Merit Review.  In August 2010, Dr. Capadona began a tenure track appointment in the Department of Biomedical Engineering at Case Western Reserve University. Dr. Capadona has co-authored two patents, two book chapters, ~95 scientific abstracts and ~31 peer reviewed scientific manuscripts, including one in Science and another that received the cover of Nature Nanotechnology.  His research articles have been cited over 1840 times. Dr. Capadona’s recent awards include: the Case School of Engineering Faculty Research Award, multiple graduate student mentoring awards, and the 2011 Presidential Early Career Award for his work on the development of bio-inspired materials for long-term implantable neurological devices at the Department of Veterans Affairs, under the umbrella of Rehabilitation R&D.


Selected Links:

Current CV

Capadona Lab – Bio-inspired Materials for Neural Interfacing

BME Jobs

Department of Biomedical Engineering

Advanced Platform Technology Center

Louis Stokes Cleveland VA Medical Center, Research

Neural Engineering Center at Case

Biomedical Engineering Society

Society For Biomaterials

National Science Foundation

National Institute of Biomedical Imaging and Bioengineering

National Institute of Neurological Disorders and Stroke


Research Statement:

            Brain interfaces for neural unit recording have led to many significant insights into the behavior of the brain in animal models. Recently, there have been several notable efforts to develop electrodes that can be implanted chronically in humans to establish direct interfaces to the brain for command, control, and feedback in many applications. Arguably, one of the largest impediments to wide-spread adoption of such neuroprosthetic devices is the unpredictable reliability of chronic neural recordings. For many years, it has been accepted as dogma that the glial scar response to implanted electrodes contributed significantly to failure of chronic neural recordings, but direct evidence for this hypothesis is only now being generated.

            Our long-term goal is to develop advanced materials for neural interfaces which will seamlessly assimilate within the neural tissue to facilitate sustained molecular level connections with individual neurons. To accomplish this goal, the materials must chronically mediate the inflammatory response and interact with the normal cellular machinery. Towards that goal, we are 1) developing novel modalities for assessing the cortical tissue-electrode interface; 2) providing new insights into the molecular and cellular level interactions at the interface; and 3) engineering biomimetic materials which facilitate mechanical, chemical, and biological device integration into normal healthy neuronal tissue while attenuating the undesired neurodegeneration and imminent device failure.

            Ultimately, devices fabricated from the advances established within my laboratory will be disseminated amongst the neuroscience and neural engineering community to improve the quality of life of those suffering poor neurological health.


Original Research Papers:

Full citation list available through Google Scholar



J.R. Capadona, S.J. Rowan, K. Shanmuganathan, D.J. Tyler, O. van den Berg, C. Weder, “Inducing modulus change in polymer nanocomposite used in biomedicals, by providing nanocomposite comprising nanoparticle network incorporated into host matrix polymer; and exposing to stimulus that reduces interactions among nanoparticles.”

Patent Number(s): US2009318590-A1

Patent Assignee(s) and Codes(s):UNIV CASE WESTERN RESERVE(UCWR-C)


C. Weder, J.R. Capadona, and O. van den Berg. “Production of polymer nanocomposite involves forming nanoparticle-containing gel having nanoparticle network, combining gel with solution including matrix polymer, and drying the composition.”

Patent Number(s): US2008242765-A1

Patent Assignee(s) and Codes(s):UNIV CASE WESTERN RESERVE(UCWR-C)



Located in Cleveland, Ohio, Case Western Reserve University is one of the nation's top research universities.
© Copyright Case Western Reserve University | Cleveland, Ohio 44106 | 216-368-2000 | | legal notice