|Jeffrey R. Capadona, Ph.D.
Dr. Capadona was born in 1978 in the southwest suburbs of Chicago, IL. He attended Saint Joseph’s College in Rensselaer, IN on an academic and athletic (baseball) scholarship. In May 2000, Dr. Capadona received his B.S. in Chemistry, and move to Atlanta, GA to attend Georgia Institute of Technology. In 2005, Dr. Capadona completed his Ph.D. thesis studying the effects of surface properties of biomedical implants on the control of cellular response and function. In June of 2005, Dr. Capadona began his career with the Department of Veterans Affairs as a Research Health Scientist. At this point, Dr. Capadona became interested in the neurodegenerative response to implanted biomedical devices. Since joining the VA, Dr. Capadona has received an Associate Investigator Award, a Career Development Award II, and is currently the PI of two Rehabilitation R&D Merit Review. In August 2010, Dr. Capadona began a tenure track appointment in the Department of Biomedical Engineering at Case Western Reserve University. Dr. Capadona has co-authored two patents, two book chapters, ~95 scientific abstracts and ~31 peer reviewed scientific manuscripts, including one in Science and another that received the cover of Nature Nanotechnology. His research articles have been cited over 1840 times. Dr. Capadona’s recent awards include: the Case School of Engineering Faculty Research Award, multiple graduate student mentoring awards, and the 2011 Presidential Early Career Award for his work on the development of bio-inspired materials for long-term implantable neurological devices at the Department of Veterans Affairs, under the umbrella of Rehabilitation R&D.
Current CV (pdf)
Brain interfaces for neural unit recording have led to many significant insights into the behavior of the brain in animal models. Recently, there have been several notable efforts to develop electrodes that can be implanted chronically in humans to establish direct interfaces to the brain for command, control, and feedback in many applications. Arguably, one of the largest impediments to wide-spread adoption of such neuroprosthetic devices is the unpredictable reliability of chronic neural recordings. For many years, it has been accepted as dogma that the glial scar response to implanted electrodes contributed significantly to failure of chronic neural recordings, but direct evidence for this hypothesis is only now being generated.
Our long-term goal is to develop advanced materials for neural interfaces which will seamlessly assimilate within the neural tissue to facilitate sustained molecular level connections with individual neurons. To accomplish this goal, the materials must chronically mediate the inflammatory response and interact with the normal cellular machinery. Towards that goal, we are 1) developing novel modalities for assessing the cortical tissue-electrode interface; 2) providing new insights into the molecular and cellular level interactions at the interface; and 3) engineering biomimetic materials which facilitate mechanical, chemical, and biological device integration into normal healthy neuronal tissue while attenuating the undesired neurodegeneration and imminent device failure.
Ultimately, devices fabricated from the advances established within my laboratory will be disseminated amongst the neuroscience and neural engineering community to improve the quality of life of those suffering poor neurological health.
Original Research Papers:
36. M. Ravikumar, S. Sunil, J. Black, D. Barkauskas, A.Y. Haung, R.H. Miller, S.M. Selkirk, and J.R. Capadona*. “The Roles of Blood-derived Macrophages and Resident Microglia in the Neuroinflammatory Response to Implanted Intracortical Microelectrodes.” Biomaterials (accepted with no scientific revision).
35. J.K. Nguyen, D.J. Park, J.L. Skousen, A.E. Hess-Dunning, D.J. Tyler, S.J. Rowan, C. Weder, and J.R. Capadona*. “Mechanically-Compliant Intracortical Implants Reduce the Neuroinflammatory Response.” J. Neural Eng. 2014 (accepted with minor revisions).
34. A. Hess-Dunning, L. Hsu, J.R. Capadona, C. Weder, S.J. Rowan, D.J. Tyler, and C.A. Zorman. “Mechanically-Adaptive Implantable Biosensors Using a Polymer Nanocomposite with Cotton-derived Cellulose Nanocrystals.” under revision (IEEE Journal of Microelectromechanical Systems. 2014 (accepted with minor revisions).
33. K.A. Potter-Baker1, M. Ravikumar1, A. Burke, W. Meador, K. Householder, A. Buck, S. Sunil, W. Stewart, J. Anna, W. Tomaszewski,J.R. Capadona*. “A Comparison of Neuroinflammation to Implanted Microelectrodes in Rat and Mouse Models.” Biomaterials, 2014, 34; 5637-5646.
32. K.A. Potter, J.K. Nguyen, K. Kovach, M. Gitomer, T.W Srail, W.G. Stewart, J.L. Skousen, J.R. Capadona*. “Development of Superoxide Dismutase Mimetic Surfaces to Reduce Accumulation of Reactive Oxygen Species for Neural Interfacing Applications” Journal of Materials Chemistry B; 2(16); 2248 DOI: 10.1039/C4TB00125G
31. K. Kovach, J.R. Capadona, A. Sen Gupta, J. Potkay. “The Effects of Efficient Surface Modification of PDSM Microchannels on Hemocompatibility” J. Biomed. Mater. Res. A.; 2014, doi:10.1002/jbm.a.35090. (available on line)
30. K.A. Potter, M. Jorfi, K.T. Householder, E.J. Foster, C. Weder, J.R. Capadona*.“Curcumin-releasing mechanically-adaptive intracortical implants improve neuronal density and blood-brain barrier stability at the implant-tissue interface.” Acta Biomaterila; 2014, 10; 2209-2222.
29. M. Ravikumar, D. Hageman, W. Tomaszewski, G. Chandra, J.L Skousen, and J.R. Capadona*. “The Effect of
Residual Bacterial Contamination on the Neuroinflammatory Response to Sterilized Intracortical Microelectrodes.” Journal of Materials Chemistry B 2014 Emerging Investigators Themed Issue, 2014,2(17); 2517-2529.
28. K.A. Potter, A. Buck, S. Sunil, M. Callanan, W.K. Self, and J.R. Capadona*. “ The Effect of Resveratrol on Neurodegeneration and Blood Brain Barrier Stability Surrounding Intracortical Microelectrodes.” Biomaterials, 2013, 34(29); 7001-7015.
27. J.D, Fox, K.A. Potter, J.R. Capadona,P.D. Marasco, and S.J. Rowan. “Bioinspired Water-enhanced Mechanical Gradient
Nanocomposite Films that Mimic the Architecture and Properties of the Squid Beak.” JACS, 135(13); 5167.
26. A.E. Hess*, K. Potter, C.A. Zorman, and J.R. Capadona*. “ Environmentally-controlled Microtensile Testing of Mechanically-Dynamic Polymer Nanocomposites for Ex Vivo Characterization.” JoVE .2012. e50078.
25. M. Ravikumar, S. Jain, R.H. Miller, J.R. Capadona, S.M. Selkirk. “An Organotypic Spinal Cord Slice Culture Model to Assess Neurodegeneration.” J. Neurosci Meth, 2012, 211(2); 280-288.
24. K.A. Potter, A.C. Buck, W.K. Self, J.R. Capadona*. “Stab Injury and Device Implantation within the Brain Results in Inversely Multiphasic Neuroinflammatory and Neurodegenerative Responses.” J. Neural Eng. 2012, 9, 046020.
23. J. R. Capadona*, D.J. Tyler, C.A. Zorman, S. J. Rowan, and C. Weder, “Mechanically Adaptive Nanocomposites for Neural Interfacing,” MRS Bulletin – Materials for Neural Interfacing. 37(6); 557-561.
22. K.A. Potter, J.S. Simon, B. Velagapudi, J.R. Capadona*. “Reduction of autofluorescence at the microelectrode-cortical tissue interface improves antibody detection.” J. Neurosci Meth. 2012, 203(1); 96-105.
21. J.P. Harris, J.R. Capadona, R.H. Miller, B.C. Healy, K. Shanmuganathan, S.J. Rowan, C. Weder, D.J. Tyler. “Mechanically Adaptive Intracortical Implants Improve the Proximity of Neuronal Cell Bodies.” J. Neural Eng. 2011, 8; (046010).
20. J.P. Harris, A.E. Hess, S.J. Rowan, C. Weder, C.A. Zorman, D.J. Tyler, J.R. Capadona*. “In vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes.” J. Neural Eng. 2011, 8; (on line version: 046010). Highlights Collection for 2011.
19. S. Padalkar, J.R. Capadona, S.J. Rowan, C. Weder, L.A. Stanciu, and R. J. Moon. “Self-Assembly and Alignment of Semiconductor Nanoparticles on Cellulose Nanocrystals.” Langmuir. 2011, 46; 5672-5679.
18. A.E. Hess, J.R. Capadona, K. Shanmuganathan, S.J Rowan, C. Weder, D.J. Tyler, C.A. Zorman. “ Development of a stimuli-responsive polymer nanocomposite toward biologically-optimized, MEMS-based neural probes.” J. Micromechan.Microeng. 2011, 21; 054009 (http://dx.doi.org/10.1088/0960-1317/21/5/054009).
17. A.E. Hess,K. Shanmuganathan, J.R. Capadona, L. Hsu. S.J Rowan, C. Weder, D.J. Tyler, C.A. Zorman. “Mechanical behaviour of microstructures from a chemo-responsive polymer nanocomposite based on cotton cellulose nanofibers.” MEMS 2011, Cancun, MEXICO, January 23-27, 2011; 453-456.
16. S. Padalkar, J.R. Capadona, S.J. Rowan, C. Weder, Y-H. Won, L.A. Stanciu, and R.J. Moon. “Natural Biopolymers: Novel Templates for the Synthesis of Nanostructures.” Langmuir. 2010, 26(11); 8497-8502 [ISSN: 0743-7463].
15. K. Shanmuganathan, J.R. Capadona, S.J. Rowan, and C. Weder. “Stimuli-Responsive Mechanically Adaptive Polymer Nanocomposites.” Appl. Mat. Interf. 2010, 2(1); 165-174 [ISSN: 1944-8244].
14. S.J. Eichhorn, A. Dufresne, M. Aranguren, J.R. Capadona, S.J. Rowan, C. Weder, W. Thielemans, M. Roman, S. Renneckar, W. Gindl, S. Weigel, H. Yano, K. Abe, M. Nogi, A. Mangalam, J. Simonsen, A.D. Benight, A. Bismarck, L.A. Berglund. Review: “Current International Research into Cellulose Nanofibres and Nanocomposites.” J. Mater. Sci. 2010, 45(1); 1-33 [ISSN: 0022-2461].
13. K. Shanmuganathan, J.R. Capadona, S.J. Rowan, and C. Weder. “Bio-inspired mechanically-adaptive nanocomposites derived from cotton cellulose whiskers.” J. Mater. Chem. 2010, 20; 180–186 [ISSN: 0959-9428].
12. K. Shanmuganathan, J.R. Capadona, S.J. Rowan, and C. Weder. “Biomimetic Mechanically Adaptive Nanocomposites.” Progr. Polym. Sci. 2010, 35; 212–222 [ISSN: 0079-6700].
11. A. Hess, J. Dunning. J. Harris. J.R. Capadona, K. Shanmuganathan, S.J. Rowan, C. Weder, D.J. Tyler, and C. Zorman. “A bio-inspired, chemo-responsive polymer nanocomposite for mechanically dynamic microsystems.” Solid-State Sensors, Actuators and Microsystems Conf., 2009. TRANSDUCERS 2009. International pp 224–7.
10. J.E. Raynor, J.R. Capadona, T.A. Petrie,A.J. García, and D.M. Collard. “Polymer brushes and self-assembled monolayers: Versatile platforms to control cell adhesion to biomaterials (Review).” Biointerphases. 2009, 4(2); FA3–FA16 (Cover) [ISSN: 1559-4106].
9. J.R. Capadona, K. Shanmuganathan, S. Trittschuh, S. Seidel, S.J. Rowan, and C. Weder. “Polymer Nanocomposites with Microcrystalline Cellulose.” Biomacromolecules. 2009, 10(4); 712–716 [ISSN: 1525-7797].
8. J.R. Capadona, K. Shanmuganathan, D.J. Tyler, S.J. Rowan, C. Weder. “Stimuli-responsive polymer nanocomposites inspired by the sea cucumber dermis.” Science. 2008, 319(5869); 1370–1374 [ISSN: 0036-8075].
7. J.R. Capadona, O. van den Berg, L.A. Capadona, M. Schroeter, S.J. Rowan, D.J. Tyler, C. Weder. “A versatile approach for the processing of polymer nanocomposites with self-assembled nanofibre templates.” Nature Nanotech. 2007, 2(12); 765–769 (Cover) [ISSN: 1748-3387].
6. O. van den Berg, M. Schroeter, J.R. Capadona, and C. Weder. “Nanocomposites based on cellulose whiskers and (semi)conducting conjugated polymers.” J. Mater. Chem. 2007; 17(26); 2746–2753 [ISSN: 0959-9428].
5. O. van den Berg, J.R. Capadona, and C. Weder. “Preparation of homogeneous dispersions of tunicate cellulose whiskers in organic solvents.” Biomacromolecules. 2007, 8(4): 1353–1357 [ISSN: 1525-7797].
4. T.A. Petrie, J.R. Capadona, C.D. Reyes, and A.J. García. “Integrin specificity and enhanced cellular activities associated with surfaces presenting a recombinant fibronectin fragment compared to RGD supports.” Biomaterials. 2006; 27(31); 5459–5470 [ISSN: 0142-9612].
3. J.R. Capadona, T.A. Petrie, K.P. Fears, R.A. Latour, D.M. Collard, and A.J. García. “Surface-nucleated assembly of fibrillar extracelluar matrices.” Adv. Mater. 2005; 17; 2604–2608 [ISSN: 0935-9648].
2. J.R. Capadona, D.M. Collard, and A.J. García. “Fibronectin adsorption and cell adhesion to mixed monolayers of tri(ethylene glycol)- and methyl-terminated alkanethiols.” Langmuir; 2003; 19(5); 1847–1852. (Special Edition) [ISSN: 0743-7463]
1. N.D. Gallant, J.R. Capadona, A.B. Frazier, D.M. Collard, and A.J. García. “Micropatterned surfaces to engineer focal adhesions for analysis of cell adhesion strengthening.” Langmuir, 2002; 18(14); 5579–5584 [ISSN: 0743-7463].
2. J.R. Capadona* and P.D. Marasco. Chapter 33, “Brain response to neural prostheses,” Textbook of Neural Repair and Rehabilitation, 2nd Edition; Cambridge University Press, 2012 (in press).
1. K. Potter, B. Gui, and J.R. Capadona*. Chapter 3, "Biomimicry at the cell-material interface," Biomimetics - Innovation thru mimicking natures inventions; CRC Press, 2011, p95-130.
J.R. Capadona, S.J. Rowan, K. Shanmuganathan, D.J. Tyler, O. van den Berg, C. Weder, “Inducing modulus change in polymer nanocomposite used in biomedicals, by providing nanocomposite comprising nanoparticle network incorporated into host matrix polymer; and exposing to stimulus that reduces interactions among nanoparticles.”
Patent Number(s): US2009318590-A1
Patent Assignee(s) and Codes(s):UNIV CASE WESTERN RESERVE(UCWR-C)
C. Weder, J.R. Capadona, and O. van den Berg. “Production of polymer nanocomposite involves forming nanoparticle-containing gel having nanoparticle network, combining gel with solution including matrix polymer, and drying the composition.”
Patent Number(s): US2008242765-A1
Patent Assignee(s) and Codes(s):UNIV CASE WESTERN RESERVE(UCWR-C)