Primary Faculty

Miklos Gratzl, Ph.D.


Miklos Gratzl, Ph.D.
Associate Professor

Office: Room 425 Wickenden Building
Phone: (216)-368-6589 / 6585
Fax: (216)-368-4969
Email: mxg13@case.edu
Mail Address: Room 309 Wickenden Building 2071 Martin Luther King Jr. Drive Cleveland, OH 44106-7207
Selected links:

• Curriculum Vitae
• Laboratory for Biomedical Sensing >>
• PubMed Citations >>

Research Summary

Development and biomedical application of chemical sensing schemes is the focus of my laboratory. Diagnostics in 1-20 microliter body fluids and other samples is performed using micro fabricated electrochemical and optical sensors and an electrochemical micro-pH-stat. We also developed an equivalent of rotating electrode for microliter samples, called the rotating sample system. For cellular research, a diffusional microburet has been developed to continuously deliver reagents and drugs into single live cells. Fluorescence microscopy is employed to quantitate intracellular accumulation. Efflux is measured with a carbon fiber based electrochemical microsensor that can detect Adriamycin, a cancer drug, extruded from cells at very low concentrations. Neurochemical studies as well as measurements at epithelial cell layers are also performed with different microscopic sensing schemes.

Recent Publications

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Oruganti P, Gratzl M, Rate limiting hydrodynamivc resistance for controlled reagent delivery. Anal. Chem., in press.

 
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Kao LT, Shetty G, Gratzl M, Electrochemical pH-stat for microliter fluid specimens.  J. ECS, 2006.

 
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Tohda K, Gratzl M, Micro-miniature autonomous optical sensor array for monitoring ions and metabolites. Anal. Sci. 22 (7) 937-941 (2006)

 
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Tohda K, Gratzl M, Micro-miniature autonomous optical sensor array for monitoring ions and metabolites. Part 1. Design, fabrication, and data analysis. Anal. Sci., 22, 383-388 (2006) (article featured on cover of journal, and designated as "hot" article).

 
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Shetty G, Syed N, Tohda K, Gratzl M, Hydrodynamic electrochemistry in 20 mL drops in the rotating sample system. Anal. Sci.  21 (10), 1155-1160 (2005) (article featured on cover of journal).

 
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Nair S, Gratzl M, Deconvolution of concentration recordings at live cell preparations via shape error optimization. Anal. Chem., 77(9), 2875-2881 (2005).


 



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