Development and control of brain-computer-interface (BCI) technologies for restoring function to individuals who have experienced severely debilitating injuries to the nervous system, such as spinal cord injury and stroke
Biomimetic tissue engineering; innovative biomaterials and drug delivery vehicles for functional tissue regeneration and cancer therapy; control of stem cell fate decision; precise temporal and spatial presentation of signals to regulate cell behavior; mechanotransduction and the influence of mechanics on cell behavior and tissue formation; and cell-cell interactions
High resolution imaging of endogenous gene expression; definition of "molecular signatures" for imaging and treatment of cancer and other diseases; generating and utilizing genomic data to define informative targets; strategies for applying non-invasive imaging to drug development; and novel molecular imaging probes and paradigms
Advanced materials for neural interfacing; biomimetic and bio-inspired materials; host-implant integration; anti-inflammatory materials; and novel biomaterials for surface modification of cortical neuroprostheses
Control of neuroprostheses for restoration of motor function; neuromechanics; and modeling of neuromusculoskeletal systems
Research in healthcare information technology, sensors and instrumentation.
Magnetic resonance imaging; rapid magnetic resonance imaging pulse sequence development; image reconstruction from non-rectilinearly sampled data; the development of image-guided interventional MRI procedures, including percutaneous cancer and cardiovascular procedures
Neural engineering; neural interfacing; neural prostheses; computational neuroscience; neural dynamics; neuromodulation; neurophysiology and control of epilepsy
Biomaterials; instrumentation; nanoscale structure-function analysis of orthopaedic biomaterials; and scanning probe microscopy and spectroscopy of skeletal tissues
Biomedical sensing and diagnostics in vitro and in vivo; electrochemical and optical techniques; BioMEMS for cellular transport; cancer multi-drug resistance at the single cell level; and sliver sensor for multi-analyte patient monitoring
Neural engineering; neural prostheses; neurophysiology and neural control of genitourinary function; devices to restore genitourinary function; and functional neuromuscular stimulation
Fabricating multifunctional agents that facilitate diagnosing; treating and monitoring of therapies in a patient-specific manner
Restoration of movement using neuroprostheses; neuroprosthesis control system design; natural control of human movements; biomechanics of movement; computer-based modeling; and system identification
Biomaterials; synthesis of new degradable polymers; tissue engineering; spinal cord repair; retinal regeneration; and drug delivery for optic nerve preservation and repair
Drug delivery and molecular imaging; novel targeted imaging agents for molecular imaging; novel MRI contrast agents; image-guided therapy and drug delivery; polymeric drug delivery systems; multi-functional delivery systems for nucleic acids
Quantitative image analysis; Multi-modal, multi-scale correlation of massive data sets for disease diagnostics, prognostics, theragnostics: cancer applications.
Chronic high-frequency electrical stimulation of subcortical brain structures-- or deep brain stimulation (DBS)-- and its applications as a therapy for neurological disorders.
Rehabilitation engineering in spinal cord injury; neural prostheses; and functional electrical stimulation and technology transfer
Biomedical optics; real-time in-vivo microstructural, functional, and molecular imaging using optical coherence tomography; diagnosis and guided therapy for cancer, cardiovascular, and ophthalmic disease
Mass and heat transport and metabolism in cells, tissues, and organ systems; mathematical modeling and simulation of dynamic and spatially distributed systems; optimal nonlinear parameter estimation and design of experiments
Advanced signal processing and data acquisition techniques for real-time MRI
Targeted drug delivery; targeted molecular imaging; image-guided therapy; platelet substitutes; novel polymeric biomaterials for tissue engineering scaffolds
The Steinmetz Lab's vision and mission is to push to new frontiers in materials science and medicine through design, development, and testing of novel nanoscale materials using Nature's nanomaterials.
Neuromimetic neuroprostheses; sensory restoration; laryngeal neuroprostheses; clinical implementation of nerve electrodes; cortical neuroprostheses; minimally invasive implantation techniques; and modeling of neural stimulation and neuroprostheses
Affinity-based delivery of small molecule drugs and biomolecules for applications in device infection, HIV, orthopedics, cardiovascular, ophthalmology and cancer; directed differentiation of stem cells for tissue engineering applications, such as endothelial cells, cardiomyocytes, motor neurons and T-cells
Biomedical image processing; digital processing and quantitative image quality of X-ray fluoroscopy images; interventional MRI
Magnetic resonance imaging and spectroscopy; applications of MRI and MRS to cardiovascular research